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Rras RAS related [ Rattus norvegicus (Norway rat) ]

Gene ID: 361568, updated on 11-Apr-2024

Summary

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Official Symbol
Rrasprovided by RGD
Official Full Name
RAS relatedprovided by RGD
Primary source
RGD:1311443
See related
Ensembl:ENSRNOG00000037247 AllianceGenome:RGD:1311443
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
p23
Summary
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in several processes, including face morphogenesis; positive regulation of endothelial cell-matrix adhesion via fibronectin; and regulation of intracellular signal transduction. Predicted to act upstream of or within negative regulation of cell migration. Predicted to be active in plasma membrane. Orthologous to human RRAS (RAS related). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 118.3), Heart (RPKM 87.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q22
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104637061..104640841)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (95500582..95504362)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101012822..101016720)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene Bcl2 like 12 Neighboring gene interferon regulatory factor 3 Neighboring gene SR-related CTD-associated factor 1 Neighboring gene proline rich 12 Neighboring gene proline rich and Gla domain 2 Neighboring gene nitric oxide synthase interacting protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis. Flex E, et al. Hum Mol Genet, 2014 Aug 15. PMID 24705357, Free PMC Article
  2. Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype. Carta C, et al. Am J Hum Genet, 2006 Jul. PMID 16773572, Free PMC Article
  3. The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling. Sandri C, et al. Cell Res, 2012 Oct. PMID 22825554, Free PMC Article
  4. The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras. Oinuma I, et al. Science, 2004 Aug 6. PMID 15297673
  5. Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells. Huang Y, et al. Oncogene, 2004 Jan 15. PMID 14724565, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of Schwann cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in face morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in leukocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of Schwann cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial cell-matrix adhesion via fibronectin ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vasculogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras-related protein R-Ras
Names
Harvey rat sarcoma oncogene, subgroup R
Harvey rat sarcoma virus oncogene, subgroup R
RAS-related viral oncoprotein
Ras-related protein R-RAS (P23)
related RAS viral (r-ras) oncogene homolog
NP_001101951.1
XP_038938093.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108481.1 → NP_001101951.1  ras-related protein R-Ras

    See identical proteins and their annotated locations for NP_001101951.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473979
    UniProtKB/Swiss-Prot
    D3Z8L7
    Related
    ENSRNOP00000027809.4, ENSRNOT00000027809.8
    Conserved Domains (2) summary
    smart00010
    Location:42 → 193
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
    cl21455
    Location:28 → 191
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    104637061..104640841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039082165.2 → XP_038938093.1  ras-related protein R-Ras isoform X1

    Conserved Domains (1) summary
    smart00010
    Location:1 → 101
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3Z8L7.1 GenPept UniProtKB/Swiss-Prot:D3Z8L7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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