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Agl amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 362029, updated on 5-Mar-2024

Summary

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Official Symbol
Aglprovided by RGD
Official Full Name
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferaseprovided by RGD
Primary source
RGD:1306376
See related
Ensembl:ENSRNOG00000016214 AllianceGenome:RGD:1306376
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables 4-alpha-glucanotransferase activity; amylo-alpha-1,6-glucosidase activity; and carbohydrate binding activity. Involved in glycogen catabolic process; response to glucocorticoid; and response to nutrient. Located in sarcoplasmic reticulum. Used to study uremia. Human ortholog(s) of this gene implicated in glycogen storage disease III. Orthologous to human AGL (amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 1109.1), Heart (RPKM 209.7) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q42
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (207389949..207445959, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (204705053..204760966, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (219788234..219843189, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase 13 homolog Neighboring gene SAS-6 centriolar assembly protein Neighboring gene major facilitator superfamily domain containing 14A Neighboring gene uncharacterized LOC102548510 Neighboring gene solute carrier family 35 member A3 Neighboring gene uncharacterized LOC120100926 Neighboring gene uncharacterized LOC102548573 Neighboring gene ferric-chelate reductase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Hepatic and neuromuscular forms of glycogenosis type III: nine mutations in AGL. Lucchiari S, et al. Hum Mutat, 2006 Jun. PMID 16705713
  2. Glycogen debranching enzyme is associated with rat skeletal muscle sarcoplasmic reticulum. Lees SJ, et al. Acta Physiol Scand, 2004 Jun. PMID 15180797
  3. N-methyl-1-deoxynojirimycin (MOR-14), an alpha-glucosidase inhibitor, markedly improves postischemic left ventricular dysfunction. Nishida Y, et al. Heart Vessels, 2000. PMID 11766064
  4. Inhibition of glycogenolysis by a glucose analogue in the working rat heart. Depre C, et al. J Mol Cell Cardiol, 1997 Aug. PMID 9281456
  5. [Effect of biogenic amines on glycogen degradation in isolated rat hepatocytes]. Popova IA, et al. Vopr Med Khim, 1992 Mar-Apr. PMID 1413626

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 4-alpha-glucanotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 4-alpha-glucanotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 4-alpha-glucanotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables amylo-alpha-1,6-glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables amylo-alpha-1,6-glucosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables amylo-alpha-1,6-glucosidase activity ISO
Inferred from Sequence Orthology
more info
  
enables beta-maltose 4-alpha-glucanotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables carbohydrate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycogen debranching enzyme activity ISO
Inferred from Sequence Orthology
more info
  
enables polysaccharide binding ISO
Inferred from Sequence Orthology
more info
  
enables polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycogen catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycogen catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycogen catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glycogen metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to glucocorticoid IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to hormone IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to nutrient IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in inclusion body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in sarcoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
glycogen debranching enzyme
Names
amylo-1, 6-glucosidase, 4-alpha-glucanotransferase (glycogen debranching enzyme, glycogen storage disease type III)
amylo-1,6-glucosidase, 4-alpha-glucanotransferase
NP_001102034.1
XP_006233291.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108564.1 → NP_001102034.1  glycogen debranching enzyme

    See identical proteins and their annotated locations for NP_001102034.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473952
    UniProtKB/TrEMBL
    A6HVA9, D4AEH9
    Related
    ENSRNOP00000052593.2, ENSRNOT00000055735.3
    Conserved Domains (5) summary
    cd11327
    Location:105 → 583
    AmyAc_Glg_debranch_2; Alpha amylase catalytic domain found in glycogen debranching enzymes
    TIGR01531
    Location:22 → 1532
    glyc_debranch; glycogen debranching enzymye
    pfam06202
    Location:1073 → 1527
    GDE_C; Amylo-alpha-1,6-glucosidase
    pfam14699
    Location:31 → 116
    hGDE_N; N-terminal domain from the human glycogen debranching enzyme
    pfam14702
    Location:697 → 974
    hGDE_central; central domain of human glycogen debranching enzyme

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    207389949..207445959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233229.5 → XP_006233291.1  glycogen debranching enzyme isoform X1

    See identical proteins and their annotated locations for XP_006233291.1

    UniProtKB/TrEMBL
    A6HVA9, D4AEH9
    Conserved Domains (5) summary
    cd11327
    Location:105 → 583
    AmyAc_Glg_debranch_2; Alpha amylase catalytic domain found in glycogen debranching enzymes
    TIGR01531
    Location:22 → 1532
    glyc_debranch; glycogen debranching enzymye
    pfam06202
    Location:1073 → 1527
    GDE_C; Amylo-alpha-1,6-glucosidase
    pfam14699
    Location:31 → 116
    hGDE_N; N-terminal domain from the human glycogen debranching enzyme
    pfam14702
    Location:697 → 974
    hGDE_central; central domain of human glycogen debranching enzyme
Nucleotide Protein Strain
Heading Accession and Version

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