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Cwc22 CWC22 spliceosome associated protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 362153, updated on 6-Jun-2024

Summary

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Official Symbol
Cwc22provided by RGD
Official Full Name
CWC22 spliceosome associated proteinprovided by RGD
Primary source
RGD:1565385
See related
Ensembl:ENSRNOG00000012651 AllianceGenome:RGD:1565385
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565385
Summary
Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in cytosol and nuclear speck. Predicted to be part of U2-type catalytic step 1 spliceosome; U2-type catalytic step 2 spliceosome; and U2-type precatalytic spliceosome. Orthologous to human CWC22 (CWC22 spliceosome associated protein homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 104.6), Spleen (RPKM 93.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cwc22 in Genome Data Viewer
Location:
3q24
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (83222400..83271427, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (62815230..62864269, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (64731145..64780127, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 385B Neighboring gene uncharacterized LOC134486394 Neighboring gene uncharacterized LOC134486396 Neighboring gene U2 spliceosomal RNA Neighboring gene phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly. Barbosa I, et al. Nat Struct Mol Biol, 2012 Oct. PMID 22961380
  2. Structure of a human catalytic step I spliceosome. Zhan X, et al. Science, 2018 Feb 2. PMID 29301961
  3. Structure of the human activated spliceosome in three conformational states. Zhang X, et al. Cell Res, 2018 Mar. PMID 29360106, Free PMC Article
  4. Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Bertram K, et al. Nature, 2017 Feb 16. PMID 28076346
  5. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. Jurica MS, et al. RNA, 2002 Apr. PMID 11991638, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of U2-type catalytic step 1 spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type precatalytic spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pre-mRNA-splicing factor CWC22 homolog
Names
CWC22 homolog, spliceosome-associated protein
CWC22 spliceosome associated protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399981.1 → NP_001386910.1  pre-mRNA-splicing factor CWC22 homolog

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HMK0, F1LY38
    Related
    ENSRNOP00000039180.6, ENSRNOT00000037684.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    83222400..83271427 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008761966.2 → XP_008760188.1  pre-mRNA-splicing factor CWC22 homolog isoform X1

    See identical proteins and their annotated locations for XP_008760188.1

    UniProtKB/TrEMBL
    F1LY38
    Conserved Domains (2) summary
    smart00543
    Location:165 → 346
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    cl02653
    Location:457 → 563
    MA3; MA3 domain

  2. XM_008761965.4 → XP_008760187.1  pre-mRNA-splicing factor CWC22 homolog isoform X1

    See identical proteins and their annotated locations for XP_008760187.1

    UniProtKB/TrEMBL
    F1LY38
    Conserved Domains (2) summary
    smart00543
    Location:165 → 346
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    cl02653
    Location:457 → 563
    MA3; MA3 domain

  3. XM_063284136.1 → XP_063140206.1  pre-mRNA-splicing factor CWC22 homolog isoform X4

    UniProtKB/TrEMBL
    A6HMK0, F1LY38

  4. XM_006234425.5 → XP_006234487.1  pre-mRNA-splicing factor CWC22 homolog isoform X3

    See identical proteins and their annotated locations for XP_006234487.1

    UniProtKB/TrEMBL
    A0A8I6GJW5, F1LY38
    Related
    ENSRNOP00000092657.1
    Conserved Domains (3) summary
    smart00543
    Location:164 → 345
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    pfam08648
    Location:13 → 112
    DUF1777; Protein of unknown function (DUF1777)
    cl02653
    Location:456 → 562
    MA3; MA3 domain

  5. XM_008761967.4 → XP_008760189.1  pre-mRNA-splicing factor CWC22 homolog isoform X2

    See identical proteins and their annotated locations for XP_008760189.1

    UniProtKB/TrEMBL
    F1LY38
    Conserved Domains (3) summary
    smart00543
    Location:164 → 345
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    pfam08648
    Location:13 → 112
    DUF1777; Protein of unknown function (DUF1777)
    cl02653
    Location:456 → 562
    MA3; MA3 domain

  6. XM_063284137.1 → XP_063140207.1  pre-mRNA-splicing factor CWC22 homolog isoform X5

Nucleotide Protein Strain
Heading Accession and Version

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