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Elmo2 engulfment and cell motility 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362271, updated on 31-Mar-2024

Summary

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Symbol
Elmo2provided by RGD
Full Name
engulfment and cell motility 2provided by RGD
Primary source
RGD:1305784
See related
Ensembl:ENSRNOG00000018747 AllianceGenome:RGD:1305784
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable receptor tyrosine kinase binding activity. Predicted to be involved in actin filament organization and cell chemotaxis. Predicted to be located in cytosol and membrane. Orthologous to human ELMO2 (engulfment and cell motility 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 140.6), Brain (RPKM 139.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Elmo2 in Genome Data Viewer
Location:
3q42
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (174442965..174716723, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (154023661..154061259, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (161812474..161850006, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486204 Neighboring gene solute carrier family 35 member C2 Neighboring gene zinc finger protein 663 Neighboring gene zinc finger protein 334 Neighboring gene osteoclast stimulatory transmembrane protein Neighboring gene solute carrier family 13 member 3 Neighboring gene uncharacterized LOC134486203 Neighboring gene Tp53 tumor protein p53 regulating kinase A Neighboring gene solute carrier family 2 member 10 Neighboring gene uncharacterized LOC120101927 Neighboring gene EYA transcriptional coactivator and phosphatase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism. Hiramoto-Yamaki N, et al. J Cell Biol, 2010 Aug 9. PMID 20679435, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC109347

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phagocytosis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
engulfment and cell motility protein 2
Names
engulfment and cell motility 2, ced-12 homolog
engulfment and cell motility protein 2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134955.3 → NP_001128427.1  engulfment and cell motility protein 2

    See identical proteins and their annotated locations for NP_001128427.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6G6K9, A6JXF0, G3V982
    Related
    ENSRNOP00000039023.3, ENSRNOT00000049262.5
    Conserved Domains (3) summary
    cd13359
    Location:551 → 680
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:307 → 486
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:116 → 283
    DUF3361; Domain of unknown function (DUF3361)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    174442965..174716723 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284221.1 → XP_063140291.1  engulfment and cell motility protein 2 isoform X2

  2. XM_006235599.5 → XP_006235661.1  engulfment and cell motility protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006235661.1

    UniProtKB/TrEMBL
    A0A8I6G6K9, A6JXE9
    Related
    ENSRNOP00000096486.1
    Conserved Domains (3) summary
    cd13359
    Location:539 → 668
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:297 → 469
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:115 → 271
    DUF3361; Domain of unknown function (DUF3361)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013208.1: Suppressed sequence

    Description
    NM_001013208.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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