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Sumf1 sulfatase modifying factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362409, updated on 5-Mar-2024

Summary

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Official Symbol
Sumf1provided by RGD
Official Full Name
sulfatase modifying factor 1provided by RGD
Primary source
RGD:1309939
See related
Ensembl:ENSRNOG00000006813 AllianceGenome:RGD:1309939
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in post-translational protein modification and protein oxidation. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in mucosulfatidosis. Orthologous to human SUMF1 (sulfatase modifying factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 114.8), Lung (RPKM 77.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q41
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (142634766..142716726, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (141078735..141160711, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (140139017..140220482, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486830 Neighboring gene SET domain and mariner transposase fusion gene Neighboring gene uncharacterized LOC134486831 Neighboring gene inositol 1,4,5-trisphosphate receptor, type 1 Neighboring gene uncharacterized LOC102547466 Neighboring gene uncharacterized LOC108350742

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Reconstitution of Formylglycine-generating Enzyme with Copper(II) for Aldehyde Tag Conversion. Holder PG, et al. J Biol Chem, 2015 Jun 19. PMID 25931126, Free PMC Article
  2. SUMF1 mutations affecting stability and activity of formylglycine generating enzyme predict clinical outcome in multiple sulfatase deficiency. Schlotawa L, et al. Eur J Hum Genet, 2011 Mar. PMID 21224894, Free PMC Article
  3. Multiple sulfatase deficiency is caused by mutations in the gene encoding the human C(alpha)-formylglycine generating enzyme. Dierks T, et al. Cell, 2003 May 16. PMID 12757705
  4. Paralog of the formylglycine-generating enzyme--retention in the endoplasmic reticulum by canonical and noncanonical signals. Gande SL, et al. FEBS J, 2008 Mar. PMID 18266766
  5. Sulphatase activities are regulated by the interaction of sulphatase-modifying factor 1 with SUMF2. Zito E, et al. EMBO Rep, 2005 Jul. PMID 15962010, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cupric ion binding IEA
Inferred from Electronic Annotation
more info
  
enables formylglycine-generating oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in post-translational protein modification IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
formylglycine-generating enzyme
NP_001102109.1
XP_038963755.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108639.1 → NP_001102109.1  formylglycine-generating enzyme precursor

    See identical proteins and their annotated locations for NP_001102109.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473957
    UniProtKB/TrEMBL
    A0A8I5ZM54, A6IBK9, D4A7I8
    Related
    ENSRNOP00000009008.4, ENSRNOT00000009008.6
    Conserved Domains (2) summary
    TIGR03525
    Location:89 → 372
    GldK; gliding motility-associated lipoprotein GldK
    pfam03781
    Location:86 → 365
    FGE-sulfatase; Sulfatase-modifying factor enzyme 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    142634766..142716726 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107827.2 → XP_038963755.1  formylglycine-generating enzyme isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZM54
    Related
    ENSRNOP00000079041.1
    Conserved Domains (1) summary
    pfam03781
    Location:86 → 345
    FGE-sulfatase; Sulfatase-modifying factor enzyme 1
Nucleotide Protein Strain
Heading Accession and Version

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