U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ttll3 tubulin tyrosine ligase like 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362415, updated on 20-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Ttll3provided by RGD
Official Full Name
tubulin tyrosine ligase like 3provided by RGD
Primary source
RGD:1311255
See related
Ensembl:ENSRNOG00000009032 AllianceGenome:RGD:1311255
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein-glycine ligase activity, initiating. Predicted to be involved in flagellated sperm motility and protein polyglycylation. Predicted to act upstream of or within cilium assembly. Predicted to be located in axoneme; microtubule cytoskeleton; and sperm flagellum. Orthologous to human TTLL3 (tubulin tyrosine ligase like 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 65.1), Kidney (RPKM 26.4) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
4q42
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (148088575..148113526)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (146532958..146558425)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (145341059..145366614)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene transcriptional adaptor 3 Neighboring gene actin related protein 2/3 complex, subunit 4 Neighboring gene RNA pseudouridine synthase D3 Neighboring gene uncharacterized LOC102548450 Neighboring gene cell death-inducing DFFA-like effector c

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia. Bosch Grau M, et al. J Cell Biol, 2013 Aug 5. PMID 23897886, Free PMC Article
  2. Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. Rogowski K, et al. Cell, 2009 Jun 12. PMID 19524510
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-glycine ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-glycine ligase activity, initiating IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-glycine ligase activity, initiating ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
  
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axoneme ISO
Inferred from Sequence Orthology
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
tubulin monoglycylase TTLL3
Names
tubulin tyrosine ligase-like family, member 3
NP_001102110.2
XP_038963762.1
XP_038963763.1
XP_038963764.1
XP_038963765.1
XP_038963766.1
XP_038963767.1
XP_038963768.1
XP_038963769.1
XP_038963770.1
XP_038963771.1
XP_038963772.1
XP_038963773.1
XP_038963775.1
XP_038963776.1
XP_038963778.1
XP_038963779.1
XP_038963780.1
XP_038963781.1
XP_038963782.1
XP_038963783.1
XP_063142363.1
XP_063142364.1
XP_063142365.1
XP_063142366.1
XP_063142367.1
XP_063142368.1
XP_063142369.1
XP_063142370.1
XP_063142371.1
XP_063142372.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108640.2 → NP_001102110.2  tubulin monoglycylase TTLL3 isoform 1

    Status: PROVISIONAL

    Source sequence(s)
    BC168907, CV126544
    UniProtKB/TrEMBL
    B5DF33, D3ZE22
    Related
    ENSRNOP00000012015.6, ENSRNOT00000012015.8
    Conserved Domains (1) summary
    pfam03133
    Location:288 → 580
    TTL; Tubulin-tyrosine ligase family

  2. NM_001429192.1 → NP_001416121.1  tubulin monoglycylase TTLL3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

  3. NM_001429194.1 → NP_001416123.1  tubulin monoglycylase TTLL3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

  4. NM_001429195.1 → NP_001416124.1  tubulin monoglycylase TTLL3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

  5. NM_001429197.1 → NP_001416126.1  tubulin monoglycylase TTLL3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

  6. NM_001429199.1 → NP_001416128.1  tubulin monoglycylase TTLL3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

  7. NM_001429200.1 → NP_001416129.1  tubulin monoglycylase TTLL3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

  8. NM_001429203.1 → NP_001416132.1  tubulin monoglycylase TTLL3 isoform 8

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

  9. NM_001429204.1 → NP_001416133.1  tubulin monoglycylase TTLL3 isoform 9

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

  10. NM_001429205.1 → NP_001416134.1  tubulin monoglycylase TTLL3 isoform 10

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

  11. NM_001429206.1 → NP_001416135.1  tubulin monoglycylase TTLL3 isoform 11

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

  12. NM_001429207.1 → NP_001416136.1  tubulin monoglycylase TTLL3 isoform 12

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    148088575..148113526
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107845.2 → XP_038963773.1  tubulin monoglycylase TTLL3 isoform X16

    Conserved Domains (1) summary
    pfam03133
    Location:288 → 592
    TTL; Tubulin-tyrosine ligase family

  2. XM_063286301.1 → XP_063142371.1  tubulin monoglycylase TTLL3 isoform X26

  3. XM_063286298.1 → XP_063142368.1  tubulin monoglycylase TTLL3 isoform X19

  4. XM_063286299.1 → XP_063142369.1  tubulin monoglycylase TTLL3 isoform X21

  5. XM_063286302.1 → XP_063142372.1  tubulin monoglycylase TTLL3 isoform X28

  6. XM_039107847.2 → XP_038963775.1  tubulin monoglycylase TTLL3 isoform X17

    Conserved Domains (1) summary
    pfam03133
    Location:287 → 591
    TTL; Tubulin-tyrosine ligase family

  7. XM_039107843.2 → XP_038963771.1  tubulin monoglycylase TTLL3 isoform X13

    UniProtKB/TrEMBL
    A0A8I6ABR5
    Conserved Domains (1) summary
    pfam03133
    Location:439 → 743
    TTL; Tubulin-tyrosine ligase family

  8. XM_039107842.2 → XP_038963770.1  tubulin monoglycylase TTLL3 isoform X11

    UniProtKB/TrEMBL
    A0A8I6ABR5
    Conserved Domains (1) summary
    pfam03133
    Location:439 → 743
    TTL; Tubulin-tyrosine ligase family

  9. XM_039107834.2 → XP_038963762.1  tubulin monoglycylase TTLL3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ABR5
    Conserved Domains (1) summary
    pfam03133
    Location:439 → 743
    TTL; Tubulin-tyrosine ligase family

  10. XM_039107837.2 → XP_038963765.1  tubulin monoglycylase TTLL3 isoform X4

    UniProtKB/TrEMBL
    A0A8I6ABR5
    Conserved Domains (1) summary
    pfam03133
    Location:439 → 743
    TTL; Tubulin-tyrosine ligase family

  11. XM_039107851.2 → XP_038963779.1  tubulin monoglycylase TTLL3 isoform X24

    UniProtKB/TrEMBL
    A0A8I6ABR5
    Conserved Domains (1) summary
    pfam03133
    Location:439 → 743
    TTL; Tubulin-tyrosine ligase family

  12. XM_039107844.2 → XP_038963772.1  tubulin monoglycylase TTLL3 isoform X14

    UniProtKB/TrEMBL
    A0A8I6ABR5
    Related
    ENSRNOP00000088967.1
    Conserved Domains (1) summary
    pfam03133
    Location:439 → 731
    TTL; Tubulin-tyrosine ligase family

  13. XM_063286295.1 → XP_063142365.1  tubulin monoglycylase TTLL3 isoform X12

  14. XM_039107836.2 → XP_038963764.1  tubulin monoglycylase TTLL3 isoform X3

    UniProtKB/TrEMBL
    A0A8I6ABR5
    Conserved Domains (1) summary
    pfam03133
    Location:439 → 731
    TTL; Tubulin-tyrosine ligase family

  15. XM_063286293.1 → XP_063142363.1  tubulin monoglycylase TTLL3 isoform X5

  16. XM_039107852.2 → XP_038963780.1  tubulin monoglycylase TTLL3 isoform X25

    UniProtKB/TrEMBL
    A0A8I6ABR5
    Conserved Domains (1) summary
    pfam03133
    Location:439 → 731
    TTL; Tubulin-tyrosine ligase family

  17. XM_039107840.2 → XP_038963768.1  tubulin monoglycylase TTLL3 isoform X8

    UniProtKB/TrEMBL
    A0A8I5Y527
    Conserved Domains (1) summary
    pfam03133
    Location:404 → 708
    TTL; Tubulin-tyrosine ligase family

  18. XM_039107841.2 → XP_038963769.1  tubulin monoglycylase TTLL3 isoform X9

    UniProtKB/TrEMBL
    A0A8I5Y527
    Conserved Domains (1) summary
    pfam03133
    Location:404 → 696
    TTL; Tubulin-tyrosine ligase family

  19. XM_039107853.2 → XP_038963781.1  tubulin monoglycylase TTLL3 isoform X27

    UniProtKB/TrEMBL
    A0A8I5Y527
    Conserved Domains (1) summary
    pfam03133
    Location:404 → 696
    TTL; Tubulin-tyrosine ligase family

  20. XM_039107835.2 → XP_038963763.1  tubulin monoglycylase TTLL3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6ABR5
    Conserved Domains (1) summary
    pfam03133
    Location:438 → 742
    TTL; Tubulin-tyrosine ligase family

  21. XM_039107855.2 → XP_038963783.1  tubulin monoglycylase TTLL3 isoform X30

    UniProtKB/TrEMBL
    A0A8I6ABR5
    Conserved Domains (1) summary
    pfam03133
    Location:438 → 730
    TTL; Tubulin-tyrosine ligase family

  22. XM_039107838.2 → XP_038963766.1  tubulin monoglycylase TTLL3 isoform X6

    UniProtKB/TrEMBL
    A0A8I6ABR5
    Conserved Domains (1) summary
    pfam03133
    Location:407 → 711
    TTL; Tubulin-tyrosine ligase family

  23. XM_063286297.1 → XP_063142367.1  tubulin monoglycylase TTLL3 isoform X18

  24. XM_063286294.1 → XP_063142364.1  tubulin monoglycylase TTLL3 isoform X10

  25. XM_063286300.1 → XP_063142370.1  tubulin monoglycylase TTLL3 isoform X22

  26. XM_039107839.2 → XP_038963767.1  tubulin monoglycylase TTLL3 isoform X7

    UniProtKB/TrEMBL
    A0A8I6ABR5
    Conserved Domains (1) summary
    pfam03133
    Location:406 → 710
    TTL; Tubulin-tyrosine ligase family

  27. XM_063286296.1 → XP_063142366.1  tubulin monoglycylase TTLL3 isoform X15

  28. XM_039107848.2 → XP_038963776.1  tubulin monoglycylase TTLL3 isoform X20

    Conserved Domains (1) summary
    pfam03133
    Location:258 → 562
    TTL; Tubulin-tyrosine ligase family

  29. XM_039107850.2 → XP_038963778.1  tubulin monoglycylase TTLL3 isoform X23

    Conserved Domains (1) summary
    pfam03133
    Location:237 → 541
    TTL; Tubulin-tyrosine ligase family

  30. XM_039107854.1 → XP_038963782.1  tubulin monoglycylase TTLL3 isoform X29

    Conserved Domains (1) summary
    pfam03133
    Location:1 → 233
    TTL; Tubulin-tyrosine ligase family

RNA

  1. XR_005503258.2 RNA Sequence

  2. XR_005503259.2 RNA Sequence

  3. XR_010065676.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous