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Hebp1 heme binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362454, updated on 13-Apr-2024

Summary

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Official Symbol
Hebp1provided by RGD
Official Full Name
heme binding protein 1provided by RGD
Primary source
RGD:1304581
See related
Ensembl:ENSRNOG00000000024 AllianceGenome:RGD:1304581
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable heme binding activity. Predicted to be located in cytosol. Orthologous to human HEBP1 (heme binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 150.7), Spleen (RPKM 116.2) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q43
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (169705665..169735199, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (167974316..168003854, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (168903586..168933102, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor, class C, group 5, member D Neighboring gene ribosomal protein S17, pseudogene 7 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene family with sequence similarity 234, member B Neighboring gene germ cell associated 1 Neighboring gene phosphatidylethanolamine binding protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular characterization of a newly identified heme-binding protein induced during differentiation of urine erythroleukemia cells. Taketani S, et al. J Biol Chem, 1998 Nov 20. PMID 9813049
  2. The first structure from the SOUL/HBP family of heme-binding proteins, murine P22HBP. Dias JS, et al. J Biol Chem, 2006 Oct 20. PMID 16905545
  3. Characterization of a human and mouse tetrapyrrole-binding protein. Jacob Blackmon B, et al. Arch Biochem Biophys, 2002 Nov 15. PMID 12413491
  4. Discovery of a putative heme-binding protein family (SOUL/HBP) by two-tissue suppression subtractive hybridization and database searches. Zylka MJ, et al. Brain Res Mol Brain Res, 1999 Dec 10. PMID 10640688
  5. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
heme-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108651.1 → NP_001102121.1  heme-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001102121.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473964
    UniProtKB/TrEMBL
    A6IMF8
    Conserved Domains (1) summary
    pfam04832
    Location:30 → 131
    SOUL; SOUL heme-binding protein

  2. NM_001398876.1 → NP_001385805.1  heme-binding protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A9K3Y6Z3, B4F7C7, F7EVC6
    Related
    ENSRNOP00000000025.7, ENSRNOT00000000025.8
    Conserved Domains (1) summary
    pfam04832
    Location:13 → 188
    SOUL; SOUL heme-binding protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    169705665..169735199 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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