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C2cd5 C2 calcium-dependent domain containing 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362461, updated on 3-Apr-2024

Summary

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Official Symbol
C2cd5provided by RGD
Official Full Name
C2 calcium-dependent domain containing 5provided by RGD
Primary source
RGD:1304592
See related
Ensembl:ENSRNOG00000014382 AllianceGenome:RGD:1304592
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1304592
Summary
Predicted to enable calcium ion binding activity and calcium-dependent phospholipid binding activity. Predicted to be involved in several processes, including insulin receptor signaling pathway via phosphatidylinositol 3-kinase; positive regulation of transport; and protein localization to plasma membrane. Predicted to act upstream of or within positive regulation of glucose import and vesicle fusion. Predicted to be located in several cellular components, including centriolar satellite; cytoplasmic vesicle membrane; and ruffle membrane. Predicted to be active in plasma membrane. Orthologous to human C2CD5 (C2 calcium dependent domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 106.0), Thymus (RPKM 98.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q44
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (177700515..177790576, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (175969544..176055597, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (177245868..177331910, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 Neighboring gene uncharacterized LOC134486862 Neighboring gene ethanolamine kinase 1 Neighboring gene uncharacterized LOC134486689

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane. Xie X, et al. Cell Metab, 2011 Sep 7. PMID 21907143, Free PMC Article
  2. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of glucose import ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of glucose transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of glucose transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of vesicle fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within vesicle fusion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
C2 domain-containing protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134581.1 → NP_001128053.1  C2 domain-containing protein 5

    See identical proteins and their annotated locations for NP_001128053.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473964
    UniProtKB/TrEMBL
    A0A0G2K543, A6IMW8
    Conserved Domains (1) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    177700515..177790576 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006237639.5 → XP_006237701.1  C2 domain-containing protein 5 isoform X36

    UniProtKB/TrEMBL
    A0A0G2K543
    Conserved Domains (1) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  2. XM_006237638.5 → XP_006237700.1  C2 domain-containing protein 5 isoform X31

    UniProtKB/TrEMBL
    A0A0G2K543, A0A8I5ZNZ8
    Related
    ENSRNOP00000079948.1
    Conserved Domains (1) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  3. XM_006237636.5 → XP_006237698.1  C2 domain-containing protein 5 isoform X24

    UniProtKB/TrEMBL
    A0A0G2K543, D4A5B3
    Related
    ENSRNOP00000059174.2
    Conserved Domains (1) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  4. XM_063286381.1 → XP_063142451.1  C2 domain-containing protein 5 isoform X21

  5. XM_063286379.1 → XP_063142449.1  C2 domain-containing protein 5 isoform X20

  6. XM_039107923.2 → XP_038963851.1  C2 domain-containing protein 5 isoform X8

    UniProtKB/TrEMBL
    A0A0G2K543
    Conserved Domains (1) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  7. XM_017592715.3 → XP_017448204.1  C2 domain-containing protein 5 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K543

  8. XM_006237640.5 → XP_006237702.1  C2 domain-containing protein 5 isoform X37

    UniProtKB/TrEMBL
    A0A0G2K543
    Related
    ENSRNOP00000088901.1
    Conserved Domains (1) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  9. XM_039107934.2 → XP_038963862.1  C2 domain-containing protein 5 isoform X28

    UniProtKB/TrEMBL
    A0A0G2K543
    Conserved Domains (1) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  10. XM_006237637.5 → XP_006237699.1  C2 domain-containing protein 5 isoform X25

    UniProtKB/TrEMBL
    A0A0G2K543
    Conserved Domains (1) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  11. XM_039107937.2 → XP_038963865.1  C2 domain-containing protein 5 isoform X33

    UniProtKB/TrEMBL
    A0A0G2K543
    Conserved Domains (1) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  12. XM_039107933.2 → XP_038963861.1  C2 domain-containing protein 5 isoform X27

    UniProtKB/TrEMBL
    A0A0G2K543
    Conserved Domains (1) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  13. XM_006237634.5 → XP_006237696.1  C2 domain-containing protein 5 isoform X19

    UniProtKB/TrEMBL
    A0A0G2K543
    Conserved Domains (1) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  14. XM_063286383.1 → XP_063142453.1  C2 domain-containing protein 5 isoform X35

    UniProtKB/TrEMBL
    A0A8I6AAM3

  15. XM_039107936.2 → XP_038963864.1  C2 domain-containing protein 5 isoform X30

    UniProtKB/TrEMBL
    A0A0G2K543
    Conserved Domains (1) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  16. XM_017592723.3 → XP_017448212.1  C2 domain-containing protein 5 isoform X23

    UniProtKB/TrEMBL
    A0A0G2K543, A0A8I6GFP7
    Related
    ENSRNOP00000087996.1

  17. XM_039107932.2 → XP_038963860.1  C2 domain-containing protein 5 isoform X26

    UniProtKB/TrEMBL
    A0A0G2K543
    Conserved Domains (1) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  18. XM_017592722.3 → XP_017448211.1  C2 domain-containing protein 5 isoform X15

    UniProtKB/TrEMBL
    A0A0G2K543

  19. XM_039107938.2 → XP_038963866.1  C2 domain-containing protein 5 isoform X34

    UniProtKB/TrEMBL
    A0A0G2K543
    Conserved Domains (1) summary
    cd08688
    Location:5 → 118
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  20. XM_039107935.2 → XP_038963863.1  C2 domain-containing protein 5 isoform X29

    UniProtKB/TrEMBL
    A0A0G2K543
    Conserved Domains (1) summary
    cd08688
    Location:5 → 118
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  21. XM_039107929.2 → XP_038963857.1  C2 domain-containing protein 5 isoform X22

    UniProtKB/TrEMBL
    A0A0G2K543
    Conserved Domains (1) summary
    cd08688
    Location:5 → 118
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  22. XM_039107927.2 → XP_038963855.1  C2 domain-containing protein 5 isoform X14

    UniProtKB/TrEMBL
    A0A0G2K543
    Conserved Domains (1) summary
    cd08688
    Location:5 → 118
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  23. XM_063286378.1 → XP_063142448.1  C2 domain-containing protein 5 isoform X18

  24. XM_039107925.2 → XP_038963853.1  C2 domain-containing protein 5 isoform X11

    UniProtKB/TrEMBL
    A0A0G2K543
    Related
    ENSRNOP00000073285.1
    Conserved Domains (1) summary
    cd08688
    Location:5 → 118
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  25. XM_063286377.1 → XP_063142447.1  C2 domain-containing protein 5 isoform X17

  26. XM_039107921.2 → XP_038963849.1  C2 domain-containing protein 5 isoform X6

    UniProtKB/TrEMBL
    A0A0G2K543
    Conserved Domains (1) summary
    cd08688
    Location:5 → 118
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  27. XM_039107918.2 → XP_038963846.1  C2 domain-containing protein 5 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K543
    Conserved Domains (1) summary
    cd08688
    Location:5 → 118
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  28. XM_063286376.1 → XP_063142446.1  C2 domain-containing protein 5 isoform X13

  29. XM_063286375.1 → XP_063142445.1  C2 domain-containing protein 5 isoform X10

  30. XM_039107920.2 → XP_038963848.1  C2 domain-containing protein 5 isoform X5

    UniProtKB/TrEMBL
    A0A0G2K543
    Conserved Domains (1) summary
    cd08688
    Location:5 → 118
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  31. XM_039107924.2 → XP_038963852.1  C2 domain-containing protein 5 isoform X9

    UniProtKB/TrEMBL
    A0A0G2K543
    Conserved Domains (1) summary
    cd08688
    Location:5 → 118
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  32. XM_039107919.2 → XP_038963847.1  C2 domain-containing protein 5 isoform X4

    UniProtKB/TrEMBL
    A0A0G2K543
    Conserved Domains (1) summary
    cd08688
    Location:5 → 118
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  33. XM_039107922.2 → XP_038963850.1  C2 domain-containing protein 5 isoform X7

    UniProtKB/TrEMBL
    A0A0G2K543
    Conserved Domains (1) summary
    cd08688
    Location:5 → 118
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  34. XM_039107916.2 → XP_038963844.1  C2 domain-containing protein 5 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K543
    Conserved Domains (1) summary
    cd08688
    Location:5 → 118
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  35. XM_063286382.1 → XP_063142452.1  C2 domain-containing protein 5 isoform X32

  36. XM_039107928.2 → XP_038963856.1  C2 domain-containing protein 5 isoform X16

    UniProtKB/TrEMBL
    A0A0G2K543
    Conserved Domains (1) summary
    cd08688
    Location:5 → 118
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  37. XM_039107926.2 → XP_038963854.1  C2 domain-containing protein 5 isoform X12

    UniProtKB/TrEMBL
    A0A0G2K543
    Conserved Domains (1) summary
    cd08688
    Location:5 → 118
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  38. XM_039107941.2 → XP_038963869.1  C2 domain-containing protein 5 isoform X40

  39. XM_039107940.2 → XP_038963868.1  C2 domain-containing protein 5 isoform X39

  40. XM_017592725.3 → XP_017448214.1  C2 domain-containing protein 5 isoform X38

  41. XM_039107942.2 → XP_038963870.1  C2 domain-containing protein 5 isoform X41

  42. XM_039107943.2 → XP_038963871.1  C2 domain-containing protein 5 isoform X42

RNA

  1. XR_010065681.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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