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Melk maternal embryonic leucine zipper kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 362510, updated on 11-Apr-2024

Summary

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Official Symbol
Melkprovided by RGD
Official Full Name
maternal embryonic leucine zipper kinaseprovided by RGD
Primary source
RGD:1308974
See related
Ensembl:ENSRNOG00000013598 AllianceGenome:RGD:1308974
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium ion binding activity; non-membrane spanning protein tyrosine kinase activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including intracellular signal transduction; positive regulation of apoptotic process; and protein autophosphorylation. Predicted to act upstream of or within intrinsic apoptotic signaling pathway in response to oxidative stress. Predicted to be located in cell cortex and plasma membrane. Orthologous to human MELK (maternal embryonic leucine zipper kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 71.4), Testes (RPKM 24.5) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q22
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (63336151..63396254)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (58540393..58600562)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (59783835..59844356)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene small ribosomal subunit protein eS12-like Neighboring gene ring finger protein 38 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene heterogeneous nuclear ribonucleoprotein K-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of Melk, a new protein kinase, during early mouse development. Heyer BS, et al. Dev Dyn, 1999 Aug. PMID 10417823
  2. Cell-cycle-dependent cortical localization of pEg3 protein kinase in Xenopus and human cells. Chartrain I, et al. Biol Cell, 2006 Apr. PMID 16159311
  3. Cloning and expression of a cDNA encoding a novel protein serine/threonine kinase predominantly expressed in hematopoietic cells. Gil M, et al. Gene, 1997 Aug 22. PMID 9305775
  4. Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family. Lin ML, et al. Breast Cancer Res, 2007. PMID 17280616, Free PMC Article
  5. CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis. Mirey G, et al. Cell Cycle, 2005 Jun. PMID 15908796

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in neural precursor cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
maternal embryonic leucine zipper kinase
NP_001382535.1
XP_063143978.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395606.1 → NP_001382535.1  maternal embryonic leucine zipper kinase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    D4A6T6
    Related
    ENSRNOP00000059313.3, ENSRNOT00000066277.3
    Conserved Domains (3) summary
    cd12198
    Location:547 → 641
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    cd14341
    Location:281 → 332
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cd14078
    Location:7 → 263
    STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    63336151..63396254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287908.1 → XP_063143978.1  maternal embryonic leucine zipper kinase isoform X1

    UniProtKB/TrEMBL
    D4A6T6

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108662.1: Suppressed sequence

    Description
    NM_001108662.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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