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Zbtb40 zinc finger and BTB domain containing 40 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362635, updated on 3-Apr-2024

Summary

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Official Symbol
Zbtb40provided by RGD
Official Full Name
zinc finger and BTB domain containing 40provided by RGD
Primary source
RGD:1309866
See related
Ensembl:ENSRNOG00000022039 AllianceGenome:RGD:1309866
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309866
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cellular response to DNA damage stimulus and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZBTB40 (zinc finger and BTB domain containing 40). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 49.0), Adrenal (RPKM 39.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zbtb40 in Genome Data Viewer
Location:
5q36
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (154499952..154569390, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (149216496..149283746, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (155343823..155411086, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134487087 Neighboring gene Eph receptor A8 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC102552931 Neighboring gene Wnt family member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Matsuoka S, et al. Science, 2007 May 25. PMID 17525332
  2. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
  3. Large-scale characterization of HeLa cell nuclear phosphoproteins. Beausoleil SA, et al. Proc Natl Acad Sci U S A, 2004 Aug 17. PMID 15302935, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA damage response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191871.1 → NP_001178800.1  zinc finger and BTB domain-containing protein 40

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    D4A365
    Related
    ENSRNOP00000035665.7, ENSRNOT00000033670.7
    Conserved Domains (5) summary
    COG5048
    Location:869 → 1122
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:853 → 873
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:968 → 986
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18225
    Location:1 → 116
    BTB_POZ_ZBTB40; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40)
    pfam05605
    Location:1120 → 1174
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    154499952..154569390 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110414.2 → XP_038966342.1  zinc finger and BTB domain-containing protein 40 isoform X1

    UniProtKB/TrEMBL
    D4A365
    Conserved Domains (5) summary
    COG5048
    Location:869 → 1122
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:853 → 873
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:968 → 986
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18225
    Location:1 → 116
    BTB_POZ_ZBTB40; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40)
    pfam05605
    Location:1120 → 1174
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding

  2. XM_039110417.2 → XP_038966345.1  zinc finger and BTB domain-containing protein 40 isoform X1

    UniProtKB/TrEMBL
    D4A365
    Conserved Domains (5) summary
    COG5048
    Location:869 → 1122
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:853 → 873
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:968 → 986
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18225
    Location:1 → 116
    BTB_POZ_ZBTB40; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40)
    pfam05605
    Location:1120 → 1174
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding

  3. XM_006239232.5 → XP_006239294.1  zinc finger and BTB domain-containing protein 40 isoform X2

    UniProtKB/TrEMBL
    D4A365
    Conserved Domains (7) summary
    smart00225
    Location:25 → 116
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:869 → 1121
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:853 → 873
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:967 → 985
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:993 → 1015
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:19 → 113
    BTB; BTB/POZ domain
    pfam13465
    Location:922 → 947
    zf-H2C2_2; Zinc-finger double domain

  4. XM_039110411.2 → XP_038966339.1  zinc finger and BTB domain-containing protein 40 isoform X1

    UniProtKB/TrEMBL
    D4A365
    Conserved Domains (5) summary
    COG5048
    Location:869 → 1122
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:853 → 873
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:968 → 986
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18225
    Location:1 → 116
    BTB_POZ_ZBTB40; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40)
    pfam05605
    Location:1120 → 1174
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding

  5. XM_039110412.2 → XP_038966340.1  zinc finger and BTB domain-containing protein 40 isoform X1

    UniProtKB/TrEMBL
    D4A365
    Conserved Domains (5) summary
    COG5048
    Location:869 → 1122
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:853 → 873
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:968 → 986
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18225
    Location:1 → 116
    BTB_POZ_ZBTB40; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40)
    pfam05605
    Location:1120 → 1174
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding

  6. XM_039110413.2 → XP_038966341.1  zinc finger and BTB domain-containing protein 40 isoform X1

    UniProtKB/TrEMBL
    D4A365
    Conserved Domains (5) summary
    COG5048
    Location:869 → 1122
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:853 → 873
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:968 → 986
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18225
    Location:1 → 116
    BTB_POZ_ZBTB40; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40)
    pfam05605
    Location:1120 → 1174
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding

  7. XM_039110416.2 → XP_038966344.1  zinc finger and BTB domain-containing protein 40 isoform X1

    UniProtKB/TrEMBL
    D4A365
    Conserved Domains (5) summary
    COG5048
    Location:869 → 1122
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:853 → 873
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:968 → 986
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18225
    Location:1 → 116
    BTB_POZ_ZBTB40; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40)
    pfam05605
    Location:1120 → 1174
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding

  8. XM_063288071.1 → XP_063144141.1  zinc finger and BTB domain-containing protein 40 isoform X1

    UniProtKB/TrEMBL
    D4A365

  9. XM_063288072.1 → XP_063144142.1  zinc finger and BTB domain-containing protein 40 isoform X1

    UniProtKB/TrEMBL
    D4A365

  10. XM_039110420.2 → XP_038966348.1  zinc finger and BTB domain-containing protein 40 isoform X7

    Conserved Domains (4) summary
    COG5048
    Location:494 → 698
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:478 → 498
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:593 → 611
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05605
    Location:745 → 799
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding

  11. XM_063288073.1 → XP_063144143.1  zinc finger and BTB domain-containing protein 40 isoform X3

  12. XM_063288074.1 → XP_063144144.1  zinc finger and BTB domain-containing protein 40 isoform X4

  13. XM_063288075.1 → XP_063144145.1  zinc finger and BTB domain-containing protein 40 isoform X5

  14. XM_039110419.2 → XP_038966347.1  zinc finger and BTB domain-containing protein 40 isoform X6

    Conserved Domains (3) summary
    COG5048
    Location:756 → 957
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:853 → 873
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18225
    Location:1 → 116
    BTB_POZ_ZBTB40; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40)
Nucleotide Protein Strain
Heading Accession and Version

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