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Angel1 angel homolog 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362765, updated on 11-Apr-2024

Summary

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Official Symbol
Angel1provided by RGD
Official Full Name
angel homolog 1provided by RGD
Primary source
RGD:1306238
See related
Ensembl:ENSRNOG00000010567 AllianceGenome:RGD:1306238
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306238
Summary
Predicted to enable 3'-5'-exoribonuclease activity; eukaryotic initiation factor 4E binding activity; and protein domain specific binding activity. Predicted to be involved in RNA phosphodiester bond hydrolysis, exonucleolytic. Predicted to be located in several cellular components, including cis-Golgi network; endoplasmic reticulum; and perinuclear region of cytoplasm. Orthologous to human ANGEL1 (angel homolog 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 68.0), Brain (RPKM 32.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
6q31
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (112080074..112117178, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (106349125..106386202, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (110644327..110681397, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene poly(rC) binding protein 2, pseudogene 1 Neighboring gene vasohibin 1 Neighboring gene leucine rich repeat containing 74A Neighboring gene uncharacterized LOC108351370

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Tracking a refined eIF4E-binding motif reveals Angel1 as a new partner of eIF4E. Gosselin P, et al. Nucleic Acids Res, 2013 Sep. PMID 23814182, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables eukaryotic initiation factor 4E binding IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic initiation factor 4E binding ISO
Inferred from Sequence Orthology
more info
  
enables eukaryotic initiation factor 4E binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables protein domain specific binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cis-Golgi network IEA
Inferred from Electronic Annotation
more info
  
located_in cis-Golgi network ISO
Inferred from Sequence Orthology
more info
  
located_in cis-Golgi network ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
protein angel homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108717.1 → NP_001102187.1  protein angel homolog 1

    See identical proteins and their annotated locations for NP_001102187.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473982
    UniProtKB/Swiss-Prot
    B2RYM0
    UniProtKB/TrEMBL
    A6JE63
    Related
    ENSRNOP00000014635.3, ENSRNOT00000014635.5
    Conserved Domains (1) summary
    cl00490
    Location:245 → 660
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    112080074..112117178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594229.3 → XP_017449718.1  protein angel homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K3W9
    Related
    ENSRNOP00000072809.2
    Conserved Domains (1) summary
    cl00490
    Location:268 → 683
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  2. XM_006240392.5 → XP_006240454.1  protein angel homolog 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K3W9
    Conserved Domains (1) summary
    cl00490
    Location:258 → 673
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  3. XM_039112514.2 → XP_038968442.1  protein angel homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K3W9
    Conserved Domains (1) summary
    cl00490
    Location:268 → 683
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  4. XM_039112516.2 → XP_038968444.1  protein angel homolog 1 isoform X2

    Conserved Domains (1) summary
    cl00490
    Location:258 → 673
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  5. XM_039112517.2 → XP_038968445.1  protein angel homolog 1 isoform X3

    Conserved Domains (1) summary
    cl00490
    Location:199 → 614
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  6. XM_008764815.4 → XP_008763037.1  protein angel homolog 1 isoform X3

    Conserved Domains (1) summary
    cl00490
    Location:199 → 614
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2RYM0.2 GenPept UniProtKB/Swiss-Prot:B2RYM0

Gene LinkOut

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