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Syde1 synapse defective Rho GTPase homolog 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362842, updated on 25-Jan-2022

Summary

Official Symbol
Syde1provided by RGD
Official Full Name
synapse defective Rho GTPase homolog 1provided by RGD
Primary source
RGD:1305857
See related
Ensembl:ENSRNOG00000007307 AllianceGenome:RGD:1305857
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305857
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in positive regulation of trophoblast cell migration and regulation of cytoskeleton organization. Predicted to act upstream of or within several processes, including labyrinthine layer blood vessel development; synaptic vesicle docking; and synaptonemal complex assembly. Predicted to be located in cerebellar mossy fiber; cytosol; and synaptic membrane. Orthologous to human SYDE1 (synapse defective Rho GTPase homolog 1). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Adrenal (RPKM 107.3), Heart (RPKM 104.5) and 9 other tissues See more
Orthologs
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Genomic context

See Syde1 in Genome Data Viewer
Location:
7q11
Exon count:
8
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (11032931..11038917)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (14037646..14043632)

Chromosome 7 - NC_051342.1Genomic Context describing neighboring genes Neighboring gene caspase 14 Neighboring gene uncharacterized LOC102555134 Neighboring gene olfactory receptor 1087 Neighboring gene ilvB acetolactate synthase like Neighboring gene hypothetical protein LOC687281

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables GTPase regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cerebellar mossy fiber ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
 
located_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
rho GTPase-activating protein SYDE1
Names
protein syd-1 homolog 1
synapse defective 1, Rho GTPase, homolog 1
synapse defective protein 1 homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191876.1NP_001178805.1  rho GTPase-activating protein SYDE1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000177
    UniProtKB/TrEMBL
    D3ZZN9
    Related
    ENSRNOP00000009606.4, ENSRNOT00000009606.7
    Conserved Domains (2) summary
    PHA03247
    Location:48263
    PHA03247; large tegument protein UL36; Provisional
    cl02570
    Location:396601
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051342.1 Reference mRatBN7.2 Primary Assembly

    Range
    11032931..11038917
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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