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Rassf3 Ras association domain family member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362886, updated on 13-Apr-2024

Summary

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Official Symbol
Rassf3provided by RGD
Official Full Name
Ras association domain family member 3provided by RGD
Primary source
RGD:1311450
See related
Ensembl:ENSRNOG00000005388 AllianceGenome:RGD:1311450
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in signal transduction. Predicted to be located in cytosol and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human RASSF3 (Ras association domain family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 644.5), Lung (RPKM 374.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q22
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (58821360..58886020, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (56935888..57000554, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (63513825..63578499, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093619 Neighboring gene glucosamine (N-acetyl)-6-sulfatase Neighboring gene uncharacterized LOC134479702 Neighboring gene TANK-binding kinase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Frequent epigenetic inactivation of RASSF2 in thyroid cancer and functional consequences. Schagdarsurengin U, et al. Mol Cancer, 2010 Sep 29. PMID 20920251, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ras association domain-containing protein 3
Names
Ras association (RalGDS/AF-6) domain family 3
Ras association (RalGDS/AF-6) domain family member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108747.2 → NP_001102217.2  ras association domain-containing protein 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A6IGZ8, D4ACL6
    Related
    ENSRNOP00000007295.6, ENSRNOT00000007295.7
    Conserved Domains (2) summary
    pfam16517
    Location:188 → 226
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl28922
    Location:51 → 180
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    58821360..58886020 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079486.2 → XP_038935414.1  ras association domain-containing protein 3 isoform X1

    Conserved Domains (2) summary
    pfam16517
    Location:118 → 156
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl28922
    Location:1 → 110
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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