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Slc52a2 solute carrier family 52 member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362942, updated on 11-Apr-2024

Summary

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Official Symbol
Slc52a2provided by RGD
Official Full Name
solute carrier family 52 member 2provided by RGD
Primary source
RGD:1560410
See related
Ensembl:ENSRNOG00000032561 AllianceGenome:RGD:1560410
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
rRFT1; Gpr172a; Gpr172b; RGD1560410
Summary
Enables riboflavin transmembrane transporter activity. Involved in riboflavin transport. Is integral component of plasma membrane. Human ortholog(s) of this gene implicated in Brown-Vialetto-Van Laere syndrome 2 and riboflavin deficiency. Orthologous to several human genes including SLC52A2 (solute carrier family 52 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 50.5), Adrenal (RPKM 33.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q34
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (110126632..110146647)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (108246003..108267642)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (117605038..117608460)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene diacylglycerol O-acyltransferase 1 Neighboring gene scratch family transcriptional repressor 1 Neighboring gene transfer RNA proline (anticodon AGG) 52 Neighboring gene transmembrane protein 249 Neighboring gene F-box and leucine-rich repeat protein 6 Neighboring gene uncharacterized LOC134479929 Neighboring gene uncharacterized LOC134479928

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Riboflavin transport mediated by riboflavin transporters (RFVTs/SLC52A) at the rat outer blood-retinal barrier. Kubo Y, et al. Drug Metab Pharmacokinet, 2019 Dec. PMID 31601465
  2. Blood-to-retina transport of riboflavin via RFVTs at the inner blood-retinal barrier. Kubo Y, et al. Drug Metab Pharmacokinet, 2017 Feb. PMID 27964953
  3. SLC52A2 [p.P141T] and SLC52A3 [p.N21S] causing Brown-Vialetto-Van Laere Syndrome in an Indian patient: First genetically proven case with mutations in two riboflavin transporters. Udhayabanu T, et al. Clin Chim Acta, 2016 Nov 1. PMID 27702554, Free PMC Article
  4. Identification and functional characterization of a novel human and rat riboflavin transporter, RFT1. Yonezawa A, et al. Am J Physiol Cell Physiol, 2008 Sep. PMID 18632736
  5. Cloning and functional characterization of a gamma-hydroxybutyrate receptor identified in the human brain. Andriamampandry C, et al. FASEB J, 2007 Mar. PMID 17197387

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The obtained results suggested the involvement of riboflavin transporters (SLC52A/RFVT) at the outer BRB, and this is supported by the expression and knockdown analyses of rRFVT2 (Slc52a2) and rRFVT3 (Slc52a3).
    Title: Riboflavin transport mediated by riboflavin transporters (RFVTs/SLC52A) at the rat outer blood-retinal barrier.
  2. The function and inhibition profile suggested the involvement of riboflavin transporter 2 in riboflavin transport at the inner BRB, and this is supported by expression and knockdown analysis of rRFVT2 (Slc52a2) and rRFVT3 (Slc52a3) in TR-iBRB2 cells.
    Title: Blood-to-retina transport of riboflavin via RFVTs at the inner blood-retinal barrier.
  3. Intestinal riboflavin uptake process undergoes differentiation-dependent upregulation and suggest that this is mediated (at least in part) via transcriptional mechanisms of SLC52A1 and SLC52A3.
    Title: Differentiation-dependent regulation of intestinal vitamin B(2) uptake: studies utilizing human-derived intestinal epithelial Caco-2 cells and native rat intestine.
  4. Identification/characterization riboflavin trasporter (RFT1) as a novel riboflavin transporter.
    Title: Identification and functional characterization of a novel human and rat riboflavin transporter, RFT1.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 4-hydroxybutyrate receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables 4-hydroxybutyrate receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables riboflavin transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables riboflavin transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables riboflavin transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in flavin adenine dinucleotide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in riboflavin metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in riboflavin transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in riboflavin transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in riboflavin transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
solute carrier family 52, riboflavin transporter, member 2
Names
G protein-coupled receptor 172A
G protein-coupled receptor 172B
porcine endogenous retrovirus A receptor 2
riboflavin transporter 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109670.1 → NP_001103140.1  solute carrier family 52, riboflavin transporter, member 2

    See identical proteins and their annotated locations for NP_001103140.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473950
    UniProtKB/Swiss-Prot
    A3KN99, B5MEV3
    Conserved Domains (1) summary
    pfam06237
    Location:278 → 375
    DUF1011; Protein of unknown function (DUF1011)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    110126632..110146647
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263875.1 → XP_063119945.1  solute carrier family 52, riboflavin transporter, member 2 isoform X2

    UniProtKB/Swiss-Prot
    A3KN99, B5MEV3

  2. XM_039079554.2 → XP_038935482.1  solute carrier family 52, riboflavin transporter, member 2 isoform X2

    UniProtKB/Swiss-Prot
    A3KN99, B5MEV3
    Conserved Domains (1) summary
    pfam06237
    Location:278 → 375
    DUF1011; Protein of unknown function (DUF1011)

  3. XM_006241826.5 → XP_006241888.1  solute carrier family 52, riboflavin transporter, member 2 isoform X2

    See identical proteins and their annotated locations for XP_006241888.1

    UniProtKB/Swiss-Prot
    A3KN99, B5MEV3
    Related
    ENSRNOP00000046721.3
    Conserved Domains (1) summary
    pfam06237
    Location:278 → 375
    DUF1011; Protein of unknown function (DUF1011)

  4. XM_063263874.1 → XP_063119944.1  solute carrier family 52, riboflavin transporter, member 2 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B5MEV3.2 GenPept UniProtKB/Swiss-Prot:B5MEV3

Gene LinkOut

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