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Creld2 cysteine-rich with EGF-like domains 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362978, updated on 3-Apr-2024

Summary

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Official Symbol
Creld2provided by RGD
Official Full Name
cysteine-rich with EGF-like domains 2provided by RGD
Primary source
RGD:1310614
See related
Ensembl:ENSRNOG00000004659 AllianceGenome:RGD:1310614
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310614
Summary
Predicted to enable calcium ion binding activity and protein disulfide isomerase activity. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and extracellular space. Orthologous to human CRELD2 (cysteine rich with EGF like domains 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 251.3), Spleen (RPKM 193.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Creld2 in Genome Data Viewer
Location:
7q34
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (121788754..121796230)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (119909626..119916556)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (129812746..129819641)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547254 Neighboring gene zinc finger, BED-type containing 4 Neighboring gene ALG12, alpha-1,6-mannosyltransferase Neighboring gene transfer RNA leucine (anticodon AAG) 11 Neighboring gene Pim-3 proto-oncogene, serine/threonine kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Biosynthesis and secretion of mouse cysteine-rich with EGF-like domains 2. Oh-hashi K, et al. FEBS Lett, 2011 Aug 4. PMID 21729698
  2. CRELD2 is a novel endoplasmic reticulum stress-inducible gene. Oh-hashi K, et al. Biochem Biophys Res Commun, 2009 Sep 25. PMID 19615339
  3. The cysteine-rich with EGF-like domains 2 (CRELD2) protein interacts with the large cytoplasmic domain of human neuronal nicotinic acetylcholine receptor alpha4 and beta2 subunits. Ortiz JA, et al. J Neurochem, 2005 Dec. PMID 16238698
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC112714

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein disulfide isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein disulfide isomerase Creld2
Names
cysteine-rich with EGF-like domain protein 2
NP_001032285.1
XP_006242278.1
XP_063120016.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037208.1 → NP_001032285.1  protein disulfide isomerase Creld2 precursor

    See identical proteins and their annotated locations for NP_001032285.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098722
    UniProtKB/Swiss-Prot
    Q4G063
    UniProtKB/TrEMBL
    A0A8I6G5R7, A6K7H8
    Related
    ENSRNOP00000006357.5, ENSRNOT00000006357.6
    Conserved Domains (2) summary
    smart00261
    Location:191 → 227
    FU; Furin-like repeats
    cl00057
    Location:281 → 325
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    121788754..121796230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263946.1 → XP_063120016.1  protein disulfide isomerase Creld2 isoform X1

    UniProtKB/Swiss-Prot
    Q4G063
    UniProtKB/TrEMBL
    A6K7H8

  2. XM_006242216.5 → XP_006242278.1  protein disulfide isomerase Creld2 isoform X2

    Conserved Domains (2) summary
    smart00261
    Location:134 → 168
    FU; Furin-like repeats
    cl00057
    Location:222 → 266
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4G063.1 GenPept UniProtKB/Swiss-Prot:Q4G063

Gene LinkOut

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