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Aste1 asteroid homolog 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363130, updated on 6-Jun-2024

Summary

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Official Symbol
Aste1provided by RGD
Official Full Name
asteroid homolog 1provided by RGD
Primary source
RGD:1304643
See related
Ensembl:ENSRNOG00000013059 AllianceGenome:RGD:1304643
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1304643
Summary
Predicted to enable nuclease activity. Predicted to be involved in nucleic acid phosphodiester bond hydrolysis. Orthologous to human ASTE1 (asteroid homolog 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 63.0), Lung (RPKM 49.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Aste1 in Genome Data Viewer
Location:
8q32
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (114905349..114923775)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (106026570..106044694)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (113936991..113954833)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene microRNA 6330 Neighboring gene NIMA-related kinase 11 Neighboring gene spermine synthase, pseudogene 1 Neighboring gene apurinic/apyrimidinic endodeoxyribonuclease 2, pseudogene 1 Neighboring gene ATPase secretory pathway Ca2+ transporting 1 Neighboring gene ribosomal protein L29, pseudogene 14 Neighboring gene ribosomal protein L29

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein asteroid homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040156.2 → NP_001035246.2  protein asteroid homolog 1

    Status: VALIDATED

    Source sequence(s)
    BQ193960, JAXUCZ010000008
    UniProtKB/TrEMBL
    E9PU85
    Related
    ENSRNOP00000074497.1, ENSRNOT00000065794.4
    Conserved Domains (2) summary
    pfam12813
    Location:116 → 378
    XPG_I_2; XPG domain containing
    cl14812
    Location:1 → 173
    PIN_SF; PIN (PilT N terminus) domain: Superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    114905349..114923775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265809.1 → XP_063121879.1  protein asteroid homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K873, A6I2N2

  2. XM_063265814.1 → XP_063121884.1  protein asteroid homolog 1 isoform X7

  3. XM_063265812.1 → XP_063121882.1  protein asteroid homolog 1 isoform X5

  4. XM_063265810.1 → XP_063121880.1  protein asteroid homolog 1 isoform X2

    UniProtKB/TrEMBL
    A6I2N2

  5. XM_039081782.2 → XP_038937710.1  protein asteroid homolog 1 isoform X3

    Conserved Domains (2) summary
    pfam12813
    Location:116 → 404
    XPG_I_2; XPG domain containing
    cl28905
    Location:28 → 194
    PIN_SF; PIN (PilT N terminus) domain: Superfamily

  6. XM_063265811.1 → XP_063121881.1  protein asteroid homolog 1 isoform X4

  7. XM_063265815.1 → XP_063121885.1  protein asteroid homolog 1 isoform X8

    UniProtKB/TrEMBL
    A0A8I6AEP3

  8. XM_063265813.1 → XP_063121883.1  protein asteroid homolog 1 isoform X6

  9. XM_063265817.1 → XP_063121887.1  protein asteroid homolog 1 isoform X9

    UniProtKB/TrEMBL
    E9PU85

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001014213.1: Suppressed sequence

    Description
    NM_001014213.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein Strain
Heading Accession and Version

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