Cam Calmodulin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Camprovided by FlyBase
Official Full Name: Calmodulinprovided by FlyBase
Primary source: FLYBASE:FBgn0000253
Locus tag: Dmel_CG8472
See related: AllianceGenome:FB:FBgn0000253
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 3909; anon-EST:Posey59; Cal; Cal49A; CalA; cam; CaM; CAM; Cam1; CG8472; D-CaM; dCaM; DmCalm; DmCaM; Dmel\CG8472; l(2)03909; l(2)3909; lincRNA.S2634
Summary: Enables calcium ion binding activity; myosin V binding activity; and myosin VI head/neck binding activity. Involved in several processes, including metarhodopsin inactivation; neuron development; and regulation of ion transmembrane transporter activity. Located in several cellular components, including microtubule cytoskeleton; midbody; and rhabdomere. Part of myosin V complex; myosin VI complex; and myosin VII complex. Colocalizes with plasma membrane. Is expressed in several structures, including central nervous system; extended germ band embryo; germ layer; larval ring gland; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in catecholaminergic polymorphic ventricular tachycardia 4; familial hypertrophic cardiomyopathy; long QT syndrome 14; and long QT syndrome 15. Orthologous to several human genes including CALM1 (calmodulin 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 48F1-48F6; 2-66 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (12259398..12278809)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (8146903..8166314)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Calmodulin binds to Drosophila TRP with an unexpected mode.
Title: Calmodulin binds to Drosophila TRP with an unexpected mode.
Asp-CaM complex has a critical role in centrosome-pole cohesion and centrosome inheritance in neural stem cells
Title: An Asp-CaM complex is required for centrosome-pole cohesion and centrosome inheritance in neural stem cells.
Basal body formation in the male testes and the production of functional sperm does not rely on the PLP-CaM interaction, whereas production of functional mechanosensory neurons does.
Title: Drosophila pericentrin requires interaction with calmodulin for its function at centrosomes and neuronal basal bodies but not at sperm basal bodies.
characterized the interdomain motions in the calcium-bound state of calmodulin (Ca(2+)-CaM) using NMR chemical shifts as replica-averaged structural restraints in molecular dynamics simulations
Title: Determination of the individual roles of the linker residues in the interdomain motions of calmodulin using NMR chemical shifts.
Thus, Calmodulin and Abelson tyrosine kinase are key signaling molecules working synergistically to transduce both midline attractive and repulsive cues.
Title: Abelson tyrosine kinase and Calmodulin interact synergistically to transduce midline guidance cues in the Drosophila embryonic CNS.
potential functional role for calmodulin in regulation of the glycolytic pathway
Title: Interaction of calmodulin with the phosphofructokinase target sequence.
the direct interaction of melatonin with intact calcium-saturated CaM is calcium-dependent; Molecular dynamics simulations follow the dynamics of melatonin in the binding pocket of CaM
Title: NMR and molecular dynamics studies of the interaction of melatonin with calmodulin.
A mutation to the gene encoding calmodulin deregulates muscle contraction.
Title: Biochemical properties of V91G calmodulin: A calmodulin point mutation that deregulates muscle contraction in Drosophila.
Drosophila CaM is able to fully activate inducible nitric oxide synthase (iNOS); moreover, iNOS activation by CaM, like neuronal NOS, is not dependent on Ca2+ being bound to all four Ca2+-binding sites, but has specific and distinct requirements.
Title: Calcium-binding sites of calmodulin and electron transfer by inducible nitric oxide synthase.
null behavioral phenotype originates in the nervous system and involves a calmodulin function that requires calcium binding to all four sites of the protein
Title: Drosophila calmodulin mutants with specific defects in the musculature or in the nervous system.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables channel regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables enzyme regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables myosin V binding	IPI Inferred from Physical Interaction more info	PubMed
enables myosin VI head/neck binding	IPI Inferred from Physical Interaction more info	PubMed
enables myosin heavy chain binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament-based movement	IDA Inferred from Direct Assay more info	PubMed
involved_in autophagic cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centriole replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in kinetochore organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metarhodopsin inactivation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in muscle cell cellular homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of opsin-mediated signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in photoreceptor cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rhabdomere development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rhodopsin mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of smell	IDA Inferred from Direct Assay more info	PubMed
involved_in sensory perception of smell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	HDA more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle pole	IDA Inferred from Direct Assay more info	PubMed
part_of myosin V complex	IPI Inferred from Physical Interaction more info	PubMed
part_of myosin VI complex	IPI Inferred from Physical Interaction more info	PubMed
part_of myosin VII complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleoplasm	HDA more info	PubMed
colocalizes_with plasma membrane	HDA more info	PubMed
located_in rhabdomere	IDA Inferred from Direct Assay more info	PubMed
located_in rhabdomere	TAS Traceable Author Statement more info	PubMed
located_in spindle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: calmodulin

Names: CG8472-PA; CG8472-PB; CG8472-PC; CG8472-PD; CG8472-PE; Cam-PA; Cam-PB; Cam-PC; Cam-PD; Cam-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

12259398..12278809

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001259347.2 → NP_001246276.1 calmodulin, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246276.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P62152

UniProtKB/TrEMBL

A0A0B4LF57, C6SUZ2

Conserved Domains (1) summary

PTZ00184
Location:1 → 149

PTZ00184; calmodulin; Provisional
NM_078986.3 → NP_523710.1 calmodulin, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523710.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P62152

UniProtKB/TrEMBL

A0A0B4LF57, C6SUZ2

Related

FBpp0087109

Conserved Domains (1) summary

PTZ00184
Location:1 → 149

PTZ00184; calmodulin; Provisional
NM_001299408.1 → NP_001286337.1 calmodulin, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286337.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P62152

UniProtKB/TrEMBL

A0A0B4LF57, C6SUZ2

Conserved Domains (1) summary

PTZ00184
Location:1 → 149

PTZ00184; calmodulin; Provisional
NM_001259348.3 → NP_001246277.1 calmodulin, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246277.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P62152

UniProtKB/TrEMBL

A0A0B4LF57, C6SUZ2

Conserved Domains (1) summary

PTZ00184
Location:1 → 149

PTZ00184; calmodulin; Provisional
NM_165870.2 → NP_725120.1 calmodulin, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725120.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P62152

UniProtKB/TrEMBL

A0A0B4LF57, C6SUZ2

Related

FBpp0087110

Conserved Domains (1) summary

PTZ00184
Location:1 → 149

PTZ00184; calmodulin; Provisional

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
2BKH_B.1
2VAS_B.1
2X51_B.1
3GN4_B.1
3GN4_D.1
3GN4_F.1
3GN4_H.1
3L9I_C.1
4ANJ_B.1
4DBP_C.1
4DBQ_B.1
A0A0B4LF57		A0A0B4LF57
P62152.2		P62152