Tafazzin tafazzin, phospholipid-lysophospholipid transacylase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tafazzinprovided by RGD
Official Full Name: tafazzin, phospholipid-lysophospholipid transacylaseprovided by RGD
Primary source: RGD:1588532
See related: Ensembl:ENSRNOG00000053023 AllianceGenome:RGD:1588532
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Taz
Summary: Predicted to enable 1-acylglycerophosphocholine O-acyltransferase activity. Involved in positive regulation of ATP biosynthetic process and positive regulation of cardiolipin metabolic process. Predicted to be located in mitochondrial inner membrane and mitochondrial outer membrane. Predicted to be active in mitochondrial membrane. Human ortholog(s) of this gene implicated in Barth syndrome and dilated cardiomyopathy. Orthologous to human TAFAZZIN (tafazzin, phospholipid-lysophospholipid transacylase). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Note: Some orthologs of Taz (Gene ID: 363521) and Wwtr1 (Gene ID: 295062), such as the human and mouse orthologs, share the Taz symbol/alias in common. Taz is a widely used alternative name for WW domain-containing transcription regulator protein 1 (Wwtr1), which can be confused with the official symbol for tafazzin (Taz). [20 Dec 2019]
Expression: Biased expression in Heart (RPKM 174.1), Muscle (RPKM 168.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq37

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (157216826..157230524)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (152065539..152076178)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (156421006..156429461, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Non-canonical IKB kinases regulate YAP/TAZ and pathological vascular remodeling behaviors in pulmonary artery smooth muscle cells.
Title: Non-canonical IKB kinases regulate YAP/TAZ and pathological vascular remodeling behaviors in pulmonary artery smooth muscle cells.
Results find that knock-out of tafazzin (Taz) changed substantially the profile of fatty acids incorporated in cardiolipin (CL) and the distribution of CL species. It was further associated with decreased capacity of oxidative phosphorylation and switch to glycolysis, altered morphology and arrangement, and reduction in glioma cell proliferation.
Title: Tafazzin-dependent cardiolipin composition in C6 glioma cells correlates with changes in mitochondrial and cellular functions, and cellular proliferation.
Knock-down of tafazzin had no consequence with respect to the pattern of cellular fatty acids but caused a decrease in cell proliferation.
Title: Effects of siRNA-dependent knock-down of cardiolipin synthase and tafazzin on mitochondria and proliferation of glioma cells.
Tafazzin knockdown interrupts the neonatal ventricular fibroblast cell cycle and this in turn may contribute to fibrosis and dilated cardiomyopathy in Barth syndrome.
Title: Tafazzin knockdown interrupts cell cycle progression in cultured neonatal ventricular fibroblasts.
Data support the concept that a decreased tafazzin expression causes cardiomyocyte hypertrophy in vitro.
Title: Tafazzin knockdown causes hypertrophy of neonatal ventricular myocytes.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1-acylglycerophosphocholine O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-acylglycerophosphocholine O-acyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in cardiolipin acyl-chain remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiolipin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cardiolipin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cristae formation	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISO Inferred from Sequence Orthology more info
involved_in heart morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in hemopoiesis	ISO Inferred from Sequence Orthology more info
involved_in inner mitochondrial membrane organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial ATP synthesis coupled electron transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respiratory chain complex I assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in mitophagy	ISO Inferred from Sequence Orthology more info
involved_in muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ATP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cardiolipin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in spermatocyte division	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tafazzin

Names: Barth syndrome); cardiomyopathy, dilated 3A (X-linked); endocardial fibroelastosis 2; tafazzin (cardiomyopathy, dilated 3A (X-linked); tafazzin (cardiomyopathy, dilated 3A (X-linked); endocardial fibroelastosis 2; Barth syndrome)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025748.1 → NP_001020919.1 tafazzin

See identical proteins and their annotated locations for NP_001020919.1

Status: PROVISIONAL

Source sequence(s)

BC099221

UniProtKB/TrEMBL

A0A8I6A188, Q4KLG6

Conserved Domains (1) summary

cd07989
Location:34 → 241

LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

157216826..157230524

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099920.2 → XP_038955848.1 tafazzin isoform X3

UniProtKB/TrEMBL

A0A8I6ABG2

Related

ENSRNOP00000089301.1

Conserved Domains (1) summary

cd07989
Location:34 → 216

LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
XM_063280164.1 → XP_063136234.1 tafazzin isoform X4

UniProtKB/TrEMBL

A6KRR5
XM_039099918.2 → XP_038955846.1 tafazzin isoform X1

UniProtKB/TrEMBL

A0A0G2K0X0, A0A8I6A188

Conserved Domains (1) summary

cd07989
Location:34 → 242

LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
XM_006229599.5 → XP_006229661.1 tafazzin isoform X2

See identical proteins and their annotated locations for XP_006229661.1

UniProtKB/TrEMBL

A0A8I6A188, Q4KLG6

Conserved Domains (1) summary

cd07989
Location:34 → 241

LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
XM_039099919.2 → XP_038955847.1 tafazzin isoform X1

UniProtKB/TrEMBL

A0A0G2K0X0, A0A8I6A188

Related

ENSRNOP00000071612.2

Conserved Domains (1) summary

cd07989
Location:34 → 242

LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
XM_063280163.1 → XP_063136233.1 tafazzin isoform X2

UniProtKB/TrEMBL

Q4KLG6
XM_039099921.2 → XP_038955849.1 tafazzin isoform X5

UniProtKB/TrEMBL

A6KRR6

Conserved Domains (1) summary

cd07989
Location:17 → 204

LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
XM_039099923.2 → XP_038955851.1 tafazzin isoform X6

Conserved Domains (1) summary

cd07989
Location:1 → 111

LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like