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Iba57 iron-sulfur cluster assembly factor IBA57 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363611, updated on 5-Mar-2024

Summary

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Official Symbol
Iba57provided by RGD
Official Full Name
iron-sulfur cluster assembly factor IBA57provided by RGD
Primary source
RGD:1306000
See related
Ensembl:ENSRNOG00000068756 AllianceGenome:RGD:1306000
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306000
Summary
Predicted to be involved in iron-sulfur cluster assembly. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 74 and multiple mitochondrial dysfunctions syndrome 3. Orthologous to human IBA57 (iron-sulfur cluster assembly factor IBA57). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 97.3), Heart (RPKM 81.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Iba57 in Genome Data Viewer
Location:
10q22
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (44441579..44450368, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (43942017..43950807, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (45506124..45514909, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555997 Neighboring gene tripartite motif-containing 11 Neighboring gene uncharacterized LOC100911111 Neighboring gene obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF Neighboring gene gap junction protein, gamma 2 Neighboring gene guanylate kinase 1 Neighboring gene mitochondrial ribosomal protein L55

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Maio N, et al. Biochim Biophys Acta, 2015 Jun. PMID 25245479, Free PMC Article
  2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in iron-sulfur cluster assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
putative transferase CAF17, mitochondrial
Names
IBA57 homolog, iron-sulfur cluster assembly
IBA57 iron-sulfur cluster assembly
IBA57, iron-sulfur cluster assembly homolog
putative transferase CAF17 homolog, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108827.1 → NP_001102297.1  putative transferase CAF17, mitochondrial

    See identical proteins and their annotated locations for NP_001102297.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A6HEX8, D4ADG2
    Related
    ENSRNOP00000095371.1, ENSRNOT00000099520.1
    Conserved Domains (4) summary
    COG0354
    Location:53 → 352
    YgfZ; Folate-binding Fe-S cluster repair protein YgfZ, possible role in tRNA modification [Posttranslational modification, protein turnover, chaperones]
    TIGR03317
    Location:218 → 285
    ygfZ_signature; folate-binding protein YgfZ
    pfam08669
    Location:259 → 327
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
    cl01893
    Location:59 → 117
    GCV_T; Aminomethyltransferase folate-binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    44441579..44450368 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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