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Ube2l3 ubiquitin-conjugating enzyme E2L 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363836, updated on 30-Mar-2024

Summary

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Official Symbol
Ube2l3provided by RGD
Official Full Name
ubiquitin-conjugating enzyme E2L 3provided by RGD
Primary source
RGD:1308361
See related
Ensembl:ENSRNOG00000001862 AllianceGenome:RGD:1308361
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
UbcH7; UbcR7
Summary
Predicted to enable several functions, including ubiquitin conjugating enzyme activity; ubiquitin protein ligase binding activity; and ubiquitin-protein transferase activator activity. Involved in brain development. Located in cytosol and presynapse. Orthologous to human UBE2L3 (ubiquitin conjugating enzyme E2 L3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 290.4), Kidney (RPKM 289.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
11q23
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (97300584..97343084)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (83797722..83838862)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (88047186..88088477)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene HIC ZBTB transcriptional repressor 2 Neighboring gene 60S ribosomal protein L37 pseudogene Neighboring gene RIMS binding protein 3 Neighboring gene small nucleolar RNA SNORA51 Neighboring gene YdjC chitooligosaccharide deacetylase homolog Neighboring gene coiled-coil domain containing 116 Neighboring gene stromal cell-derived factor 2-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Novel control of S phase of the cell cycle by ubiquitin-conjugating enzyme H7. Whitcomb EA, et al. Mol Biol Cell, 2009 Jan. PMID 18946090, Free PMC Article
  2. Developmental changes in the expression of parkin and UbcR7, a parkin-interacting and ubiquitin-conjugating enzyme, in rat brain. Wang M, et al. J Neurochem, 2001 Jun. PMID 11413239
  3. Nilotinib-induced autophagic changes increase endogenous parkin level and ubiquitination, leading to amyloid clearance. Lonskaya I, et al. J Mol Med (Berl), 2014 Apr. PMID 24337465, Free PMC Article
  4. UbcH7 interacts with the glucocorticoid receptor and mediates receptor autoregulation. Garside H, et al. J Endocrinol, 2006 Sep. PMID 17003263
  5. Characterization of the mouse ubiquitin-conjugating enzyme gene UbcM4. Moynihan TP, et al. Mamm Genome, 1999 Oct. PMID 10501966

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell cycle phase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to glucocorticoid stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to steroid hormone stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ubiquitin-conjugating enzyme E2 L3
NP_001316065.1
XP_038944475.1
XP_063126745.1
XP_063126746.1
XP_063126747.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329136.1 → NP_001316065.1  ubiquitin-conjugating enzyme E2 L3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    B2RZA9, D3Z8W5
    Related
    ENSRNOP00000050143.5, ENSRNOT00000046159.5
    Conserved Domains (1) summary
    smart00212
    Location:6 → 149
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    97300584..97343084
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088547.2 → XP_038944475.1  ubiquitin-conjugating enzyme E2 L3 isoform X2

    UniProtKB/TrEMBL
    B2RZA9, D3Z8W5
    Conserved Domains (1) summary
    smart00212
    Location:6 → 149
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

  2. XM_063270677.1 → XP_063126747.1  ubiquitin-conjugating enzyme E2 L3 isoform X4

  3. XM_063270675.1 → XP_063126745.1  ubiquitin-conjugating enzyme E2 L3 isoform X1

  4. XM_063270676.1 → XP_063126746.1  ubiquitin-conjugating enzyme E2 L3 isoform X3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108847.1: Suppressed sequence

    Description
    NM_001108847.1: This RefSeq was removed because it was annotated with an incorrect coding sequence.
Nucleotide Protein Strain
Heading Accession and Version

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