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MDR1 Mdr1p [ Candida albicans SC5314 ]

Gene ID: 3639260, updated on 30-Nov-2023

Summary

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Gene symbol
MDR1
Gene description
Mdr1p
Locus tag
CAALFM_C603170CA
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Candida albicans SC5314 (strain: SC5314, nat-host: Homo sapiens, culture-collection: ATCC:MYA-2876)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida
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Genomic context

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Location:
chromosome: 6
Exon count:
1
Sequence:
Chromosome: 6; NC_032094.1 (666383..668077, complement)

Chromosome 6 - NC_032094.1Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Bmt6p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_032094.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A meta-analysis of MDR1 polymorphisms rs1128503 and rs1045642 and susceptibility to hepatocellular carcinoma. Chang Q, et al. J Int Med Res, 2019 Jul. PMID 31234681, Free PMC Article
  2. AS602801 Sensitizes Ovarian Cancer Stem Cells to Paclitaxel by Down-regulating MDR1. Yamamoto M, et al. Anticancer Res, 2019 Feb. PMID 30711936
  3. Molecular Basis of Substrate Polyspecificity of the Candida albicans Mdr1p Multidrug/H(+) Antiporter. Redhu AK, et al. J Mol Biol, 2018 Mar 2. PMID 29341887
  4. Cph1p negatively regulates MDR1 involved in drug resistance in Candida albicans. Lo HJ, et al. Int J Antimicrob Agents, 2015 Jun. PMID 25802233
  5. Inducible and constitutive activation of two polymorphic promoter alleles of the Candida albicans multidrug efflux pump MDR1. Sasse C, et al. Antimicrob Agents Chemother, 2012 Aug. PMID 22615278, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The evaluation of the overexpression of the ERG-11, MDR-1, CDR-1, and CDR-2 genes in fluconazole-resistant Candida albicans isolated from Ahvazian cancer patients with oral candidiasis.
    Title: The evaluation of the overexpression of the ERG-11, MDR-1, CDR-1, and CDR-2 genes in fluconazole-resistant Candida albicans isolated from Ahvazian cancer patients with oral candidiasis.
  2. found no significant relationship between the MDR1 rs1128503 polymorphism and susceptibility to HCC in 4 cohorts[meta-analysis, systemic review]
    Title: A meta-analysis of MDR1 polymorphisms rs1128503 and rs1045642 and susceptibility to hepatocellular carcinoma.
  3. The molecular basis of polyspecificity of Mdr1p, a major drug/H+ antiporter of Candida albicans.
    Title: Molecular Basis of Substrate Polyspecificity of the Candida albicans Mdr1p Multidrug/H(+) Antiporter.
  4. C3435T genotypes in the.MDR1 gene showed a certain predictive value for evaluating the risk of cytogenetic relapse, which can be used as a clinical biomarker
    Title: [Relation between single Nucleotide Polymorphisms of CYP3A5 Gene and MDR1 Gene Loci and Risk of CML Cytogenetic Relapse].
  5. AS602801 chemosensitizes ovarian cancer stem cells to paclitaxel by reducing the expression of MDR1
    Title: AS602801 Sensitizes Ovarian Cancer Stem Cells to Paclitaxel by Down-regulating MDR1.
  6. Taxus chinensis var.-mediated downregulation of MRP1, MDR1, and LRP might contribute to the reversal of drug resistance in non-small cell lung cancer stem cells.
    Title: Reversal of cisplatin resistance in non-small cell lung cancer stem cells by Taxus chinensis var.
  7. CYP2C19*2/*3 and MDR1 C3435T polymorphisms are important determinants of lansoprazole pharmacokinetics
    Title: Effects of genetic polymorphisms of CYP2C19*2/*3 and MDR1 C3435T on the pharmacokinetics of lansoprazole in healthy Chinese subjects.
  8. Furthermore, null mutation of CPH1 increased the expression of MDR1 as well as decreased susceptibility to fluconazole and voriconazole but not to amphotericin B.
    Title: Cph1p negatively regulates MDR1 involved in drug resistance in Candida albicans.
  9. Despite a tendency of more favorable absorption and rapid elimination of lansoprazole in wild genotype, no significant pharmacokinetics difference was observed between the wild genotype of MDR1 C3435T and its mutant types
    Title: A correlative study of polymorphisms of CYP2C19 and MDR1 C3435T with the pharmacokinetic profiles of lansoprazole and its main metabolites following single oral administration in healthy adult Chinese subjects.
  10. study found that the two MDR1 promoter alleles in strain SC5314 were equally well activated by inducing chemicals or hyperactive forms of the transcription factors Mrr1 and Cap1, which control MDR1 expression
    Title: Inducible and constitutive activation of two polymorphic promoter alleles of the Candida albicans multidrug efflux pump MDR1.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables fluconazole transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables xenobiotic transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
Mdr1p
XP_719165.2
  • Plasma membrane MDR/MFS multidrug efflux pump; methotrexate is preferred substrate; overexpression in drug-resistant clinical isolates confers fluconazole resistance; repressed in young biofilms; rat catheter biofilm induced

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_032094.1 Reference assembly

    Range
    666383..668077 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_714072.2 → XP_719165.2  Mdr1p [Candida albicans SC5314]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    A0A1D8PQ31, Q5ABU7
    UniProtKB/TrEMBL
    A0A8H6C0Z9, C4YSI7, Q09GR1, Q09GR2
    Conserved Domains (1) summary
    cd17323
    Location:119 → 557
    MFS_Tpo1_MDR_like; Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily
Nucleotide Protein
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Research Materials