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Selplg selectin P ligand [ Rattus norvegicus (Norway rat) ]

Gene ID: 363930, updated on 13-Apr-2024

Summary

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Official Symbol
Selplgprovided by RGD
Official Full Name
selectin P ligandprovided by RGD
Primary source
RGD:1307971
See related
Ensembl:ENSRNOG00000000699 AllianceGenome:RGD:1307971
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Psgl1; Selpl
Summary
Predicted to be involved in hemopoiesis; leukocyte adhesive activation; and leukocyte tethering or rolling. Predicted to act upstream of or within cellular response to interleukin-6. Predicted to be located in plasma membrane raft and uropod. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human SELPLG (selectin P ligand). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 260.0), Thymus (RPKM 153.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
12q16
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (48457102..48470444)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (42796690..42809908)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (48577905..48579196)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene coronin 1C Neighboring gene ATP synthase F(0) complex subunit C1, mitochondrial-like Neighboring gene uncharacterized LOC108352466 Neighboring gene transmembrane protein 119

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Failure of P-selectin blockade alone to protect the liver from ischemia-reperfusion injury in the isolated blood-perfused rat liver. Wyllie S, et al. World J Gastroenterol, 2008 Nov 28. PMID 19058306, Free PMC Article
  2. The sex-specific association of Met62Ile gene polymorphism in P-selectin glycoprotein ligand (PSGL-1) with carotid plaque presence: preliminary study. Zivković M, et al. Mol Biol Rep, 2012 Jun. PMID 22307784
  3. P-selectin glycoprotein ligand-1 is needed for sequential recruitment of T-helper 1 (Th1) and local generation of Th17 T cells in dextran sodium sulfate (DSS) colitis. Brown JB, et al. Inflamm Bowel Dis, 2012 Feb. PMID 22009715, Free PMC Article
  4. Evolutionary conservation of P-selectin glycoprotein ligand-1 primary structure and function. Baïsse B, et al. BMC Evol Biol, 2007 Sep 14. PMID 17868453, Free PMC Article
  5. Dynamic reorganization of flotillins in chemokine-stimulated human T-lymphocytes. Affentranger S, et al. BMC Cell Biol, 2011 Jun 22. PMID 21696602, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to interleukin-6 ISO
Inferred from Sequence Orthology
more info
  
involved_in leukocyte adhesive activation ISO
Inferred from Sequence Orthology
more info
  
involved_in leukocyte migration ISO
Inferred from Sequence Orthology
more info
  
involved_in leukocyte tethering or rolling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
  
involved_in leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of hepatocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane raft ISO
Inferred from Sequence Orthology
more info
  
located_in uropod ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
P-selectin glycoprotein ligand 1
Names
P-selectin glycoprotein ligand 1 propeptide
leukocyte cell surface adhesion molecule
selectin, platelet (p-selectin) ligand

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395153.1 → NP_001382082.1  P-selectin glycoprotein ligand 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A0A8I6A4X3, A7WPA8, F6T9E7, Q8K5B0
    Related
    ENSRNOP00000082525.1, ENSRNOT00000096864.1
    Conserved Domains (1) summary
    PRK10811
    Location:95 → 282
    rne; ribonuclease E; Reviewed

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    48457102..48470444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089642.2 → XP_038945570.1  P-selectin glycoprotein ligand 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A4X3, A7WPA8, F6T9E7, Q8K5B0
    Related
    ENSRNOP00000086974.1
    Conserved Domains (1) summary
    PRK10811
    Location:95 → 282
    rne; ribonuclease E; Reviewed

  2. XM_039089643.2 → XP_038945571.1  P-selectin glycoprotein ligand 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A4X3, A7WPA8, F6T9E7, Q8K5B0
    Conserved Domains (1) summary
    PRK10811
    Location:95 → 282
    rne; ribonuclease E; Reviewed

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013230.1: Suppressed sequence

    Description
    NM_001013230.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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