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TUP1 chromatin-silencing transcriptional regulator [ Candida albicans SC5314 ]

Gene ID: 3639369, updated on 30-Nov-2023

Summary

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Gene symbol
TUP1
Gene description
chromatin-silencing transcriptional regulator
Locus tag
CAALFM_C100060WA
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Candida albicans SC5314 (strain: SC5314, nat-host: Homo sapiens, culture-collection: ATCC:MYA-2876)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida
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Genomic context

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Location:
chromosome: 1
Exon count:
1
Sequence:
Chromosome: 1; NC_032089.1 (12163..13701)

Chromosome 1 - NC_032089.1Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Cta2p Neighboring gene diphosphomevalonate decarboxylase Neighboring gene uncharacterized protein Neighboring gene Rca1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_032089.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut. Román E, et al. Future Microbiol, 2018 Jun 1. PMID 29877100
  2. Ahr1 and Tup1 Contribute to the Transcriptional Control of Virulence-Associated Genes in Candida albicans. Ruben S, et al. mBio, 2020 Apr 28. PMID 32345638, Free PMC Article
  3. Functional Divergence of Hsp90 Genetic Interactions in Biofilm and Planktonic Cellular States. Diezmann S, et al. PLoS One, 2015. PMID 26367740, Free PMC Article
  4. An expanded genetic code in Candida albicans to study protein-protein interactions in vivo. Palzer S, et al. Eukaryot Cell, 2013 Jun. PMID 23543672, Free PMC Article
  5. Hgc1, a novel hypha-specific G1 cyclin-related protein regulates Candida albicans hyphal morphogenesis. Zheng X, et al. EMBO J, 2004 Apr 21. PMID 15071502, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ahr1 and Tup1 Contribute to the Transcriptional Control of Virulence-Associated Genes in Candida albicans.
    Title: Ahr1 and Tup1 Contribute to the Transcriptional Control of Virulence-Associated Genes in Candida albicans.
  2. TUP1 repression impairs the ability of C. albicans to colonize and be maintained in the mice gut.
    Title: TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut.
  3. Wor1 and Tup1 form the core regulatory circuit controlling the opaque transcriptional program. This model provides molecular insights on how C. albicans adapts to different host signals to undergo phenotypic switching for colonization in distinct host niches.
    Title: Wor1 establishes opaque cell fate through inhibition of the general co-repressor Tup1 in Candida albicans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
chromatin-silencing transcriptional regulator
XP_719068.2
  • Transcriptional corepressor; represses filamentous growth; regulates switching; role in germ tube induction, farnesol response; in repression pathways with Nrg1, Rfg1; farnesol upregulated in biofilm; rat catheter, Spider biofilm repressed

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_032089.1 Reference assembly

    Range
    12163..13701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_713975.2 → XP_719068.2  chromatin-silencing transcriptional regulator [Candida albicans SC5314]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    A0A1D8PC37, C4YFX2, P0CY34, P56093, Q5AB65
    UniProtKB/TrEMBL
    A0A191XT62
Nucleotide Protein
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