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MKC1 mitogen-activated serine/threonine-protein kinase [ Candida albicans SC5314 ]

Gene ID: 3639710, updated on 30-Nov-2023

Summary

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Gene symbol
MKC1
Gene description
mitogen-activated serine/threonine-protein kinase
Locus tag
CAALFM_CR00120CA
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Candida albicans SC5314 (strain: SC5314, nat-host: Homo sapiens, culture-collection: ATCC:MYA-2876)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida
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Genomic context

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See MKC1 in Genome Data Viewer
Location:
chromosome: R
Exon count:
1
Sequence:
Chromosome: R; NC_032096.1 (30873..32402, complement)

Chromosome R - NC_032096.1Genomic Context describing neighboring genes Neighboring gene Epl1p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rep1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_032096.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Mkk2 MAPKK Regulates Cell Wall Biogenesis in Cooperation with the Cek1-Pathway in Candida albicans. Román E, et al. PLoS One, 2015. PMID 26197240, Free PMC Article
  2. A contact-activated kinase signals Candida albicans invasive growth and biofilm development. Kumamoto CA. Proc Natl Acad Sci U S A, 2005 Apr 12. PMID 15800048, Free PMC Article
  3. Elevation of cell wall chitin via Ca(2+) -calcineurin-mediated PKC signaling pathway maintains the viability of Candida albicans in the absence of β-1,6-glucan synthesis. Han Q, et al. Mol Microbiol, 2019 Sep. PMID 31240791
  4. Complementary roles of the Cek1 and Cek2 MAP kinases in Candida albicans cell-wall biogenesis. Correia I, et al. Future Microbiol, 2016. PMID 26682470
  5. The Candida albicans ELMO homologue functions together with Rac1 and Dck1, upstream of the MAP Kinase Cek1, in invasive filamentous growth. Hope H, et al. Mol Microbiol, 2010 Jun. PMID 20444104

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ca2+-calcineurin is required for inducing Mkc1 phosphorylation when beta-1,6-glucan synthesis was blocked.
    Title: Elevation of cell wall chitin via Ca(2+) -calcineurin-mediated PKC signaling pathway maintains the viability of Candida albicans in the absence of β-1,6-glucan synthesis.
  2. Mkk2 mediates the phosphorylation of the Mkc1 MAPK in response to cell wall assembly interfering agents
    Title: The Mkk2 MAPKK Regulates Cell Wall Biogenesis in Cooperation with the Cek1-Pathway in Candida albicans.
  3. We identified an additional level of regulatory control in the C. albicans circuitry linking PKC signaling, Hsp90, and calcineurin as genetic reduction of Hsp90 led to depletion of the terminal MAPK, Mkc1
    Title: PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90.
  4. Physical contact results in activation of the mitogen-activated protein kinase Mkc1p, a protein that is required for invasive hyphal growth and normal biofilm development. [MKC1]
    Title: A contact-activated kinase signals Candida albicans invasive growth and biofilm development.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mitogen-activated serine/threonine-protein kinase
XP_718680.1
  • MAP kinase; role in biofilm formation, contact-induced invasive filamentation, systemic virulence in mouse, cell wall structure/maintenance, caspofungin response; phosphorylated on surface contact, membrane perturbation, or cell wall stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_032096.1 Reference assembly

    Range
    30873..32402 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_713587.1 → XP_718680.1  mitogen-activated serine/threonine-protein kinase [Candida albicans SC5314]

    See identical proteins and their annotated locations for XP_718680.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    A0A1D8PRN9, Q5AAG6
    UniProtKB/TrEMBL
    C4YNB7
    Conserved Domains (1) summary
    cd07857
    Location:27 → 377
    STKc_MPK1; Catalytic domain of the Serine/Threonine Kinase, Fungal Mitogen-Activated Protein Kinase MPK1
Nucleotide Protein
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Gene LinkOut

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Other Literature Sources
Molecular Biology Databases