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Prmt5 protein arginine methyltransferase 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 364382, updated on 6-May-2024

Summary

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Official Symbol
Prmt5provided by RGD
Official Full Name
protein arginine methyltransferase 5provided by RGD
Primary source
RGD:1309053
See related
Ensembl:ENSRNOG00000012046 AllianceGenome:RGD:1309053
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Skb1; Hrmt1l5
Summary
Predicted to enable several functions, including p53 binding activity; protein-arginine N-methyltransferase activity; and sequence-specific DNA binding activity. Involved in several processes, including liver regeneration; positive regulation of oligodendrocyte differentiation; and regulation of ERK1 and ERK2 cascade. Part of protein-containing complex. Biomarker of asthma. Orthologous to human PRMT5 (protein arginine methyltransferase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 128.5), Brain (RPKM 109.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
15p13
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (31938927..31948318, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (27968893..27978291, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (33156508..33165893, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene LDL receptor related protein 10 Neighboring gene RRAD and GEM like GTPase 2 Neighboring gene transfer RNA arginine (anticodon ACG) 3 Neighboring gene HAUS augmin-like complex, subunit 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Maintenance of SOX9 stability and ECM homeostasis by selenium-sensitive PRMT5 in cartilage. Sun M, et al. Osteoarthritis Cartilage, 2019 Jun. PMID 30858101
  2. Histone H4R3 symmetric di-methylation by Prmt5 protects against cardiac hypertrophy via regulation of Filip1L/β-catenin. Cai S, et al. Pharmacol Res, 2020 Nov. PMID 32739429
  3. Protein arginine methyltransferase 5 functions in opposite ways in the cytoplasm and nucleus of prostate cancer cells. Gu Z, et al. PLoS One, 2012. PMID 22952863, Free PMC Article
  4. Multimerization of expressed protein-arginine methyltransferases during the growth and differentiation of rat liver. Lim Y, et al. Biochim Biophys Acta, 2005 May 25. PMID 15837430
  5. Negative regulation of transcription by the type II arginine methyltransferase PRMT5. Fabbrizio E, et al. EMBO Rep, 2002 Jul. PMID 12101096, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protein Arginine Methyltransferase 5 Contributes to Paclitaxel-Induced Neuropathic Pain by Activating Transient Receptor Potential Vanilloid 1 Epigenetic Modification in Dorsal Root Ganglion.
    Title: Protein Arginine Methyltransferase 5 Contributes to Paclitaxel-Induced Neuropathic Pain by Activating Transient Receptor Potential Vanilloid 1 Epigenetic Modification in Dorsal Root Ganglion.
  2. Histone H4R3 symmetric di-methylation by Prmt5 protects against cardiac hypertrophy via regulation of Filip1L/beta-catenin.
    Title: Histone H4R3 symmetric di-methylation by Prmt5 protects against cardiac hypertrophy via regulation of Filip1L/β-catenin.
  3. Maintenance of SOX9 stability and ECM homeostasis by selenium-sensitive PRMT5 in cartilage.
    Title: Maintenance of SOX9 stability and ECM homeostasis by selenium-sensitive PRMT5 in cartilage.
  4. These data provide the first direct experimental evidence that PRMT5, a type II arginine methylase, is involved in the control of transcription and proliferation.
    Title: Negative regulation of transcription by the type II arginine methyltransferase PRMT5.
  5. analysis of structural insights into protein arginine symmetric dimethylation by PRMT5
    Title: Structural insights into protein arginine symmetric dimethylation by PRMT5.
  6. CpG-rich islands within the Id2 and Id4 genes were bound by PRMT5 and were hypomethylated in PRMT5-deficient cells, suggesting that PRMT5 plays a role in gene silencing during glial cell
    Title: Type II arginine methyltransferase PRMT5 regulates gene expression of inhibitors of differentiation/DNA binding Id2 and Id4 during glial cell differentiation.
  7. Protein arginine methyltransferase 5 regulates ERK1/2 signal transduction amplitude and cell fate through CRAF.
    Title: Protein arginine methyltransferase 5 regulates ERK1/2 signal transduction amplitude and cell fate through CRAF.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables E-box binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H2AR3 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H4R3 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone arginine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables methyl-CpG binding ISO
Inferred from Sequence Orthology
more info
  
enables methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables p53 binding ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-arginine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-arginine omega-N symmetric methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribonucleoprotein complex binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription termination ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi ribbon formation ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in circadian regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in endothelial cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in liver regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression via chromosomal CpG island methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spliceosomal snRNP assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of histone methyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in male germ cell nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of methylosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein arginine N-methyltransferase 5
Names
HMT1 hnRNP methyltransferase-like 5
SKB1 homolog
NP_001102337.2
XP_038949474.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108867.2 → NP_001102337.2  protein arginine N-methyltransferase 5

    See identical proteins and their annotated locations for NP_001102337.2

    Status: VALIDATED

    Source sequence(s)
    AI713913, BE116721, BQ210423, CB793692, CB814013, CK845516, CO573950, DY553859
    UniProtKB/TrEMBL
    A0A8I6ANJ2, A6KGU5, D4A0E8
    Related
    ENSRNOP00000016302.3, ENSRNOT00000016302.5
    Conserved Domains (3) summary
    pfam05185
    Location:295 → 464
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam17285
    Location:37 → 290
    PRMT5_TIM; PRMT5 TIM barrel domain
    pfam17286
    Location:468 → 635
    PRMT5_C; PRMT5 oligomerization domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    31938927..31948318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093546.2 → XP_038949474.1  protein arginine N-methyltransferase 5 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZP89
    Related
    ENSRNOP00000080060.1
    Conserved Domains (3) summary
    pfam05185
    Location:189 → 358
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam17285
    Location:1 → 184
    PRMT5_TIM; PRMT5 TIM barrel domain
    pfam17286
    Location:362 → 529
    PRMT5_C; PRMT5 oligomerization domain
Nucleotide Protein Strain
Heading Accession and Version

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