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Kctd12 potassium channel tetramerization domain containing 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 364458, updated on 13-Apr-2024

Summary

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Symbol
Kctd12provided by RGD
Full Name
potassium channel tetramerization domain containing 12provided by RGD
Primary source
RGD:1309421
See related
AllianceGenome:RGD:1309421
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity. Predicted to act upstream of or within regulation of G protein-coupled receptor signaling pathway. Predicted to be located in postsynaptic membrane and presynaptic membrane. Predicted to be part of receptor complex. Orthologous to human KCTD12 (potassium channel tetramerization domain containing 12). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
15q21
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (86214786..86220725, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (79800078..79806017, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (87384632..87390627, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102546300 Neighboring gene uncharacterized LOC102546379 Neighboring gene uncharacterized LOC134482003 Neighboring gene uncharacterized LOC120097063 Neighboring gene aconitate decarboxylase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. KCTD12 Auxiliary Proteins Modulate Kinetics of GABAB Receptor-Mediated Inhibition in Cholecystokinin-Containing Interneurons. Booker SA, et al. Cereb Cortex, 2017 Mar 1. PMID 27073217
  2. Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits. Schwenk J, et al. Nature, 2010 May 13. PMID 20400944
  3. The BTB domains of the potassium channel tetramerization domain proteins prevalently assume pentameric states. Smaldone G, et al. FEBS Lett, 2016 Jun. PMID 27152988
  4. D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone. Popiolek M, et al. J Biol Chem, 2011 Aug 19. PMID 21700703, Free PMC Article
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
located_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
BTB/POZ domain-containing protein KCTD12
Names
potassium channel tetramerisation domain containing 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399515.1 → NP_001386444.1  BTB/POZ domain-containing protein KCTD12

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A6HU83
    Conserved Domains (2) summary
    cd18397
    Location:32 → 131
    BTB_POZ_KCTD12_Pfetin; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 12 (KCTD12)
    cd22217
    Location:208 → 327
    H1_KCTD12; H1 domain found in potassium channel tetramerization domain-containing protein 12

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    86214786..86220725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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