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CDC28 cyclin-dependent serine/threonine-protein kinase [ Candida albicans SC5314 ]

Gene ID: 3644838, updated on 30-Nov-2023

Summary

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Gene symbol
CDC28
Gene description
cyclin-dependent serine/threonine-protein kinase
Locus tag
CAALFM_CR06050WA
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Candida albicans SC5314 (strain: SC5314, nat-host: Homo sapiens, culture-collection: ATCC:MYA-2876)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida
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Genomic context

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Location:
chromosome: R
Exon count:
1
Sequence:
Chromosome: R; NC_032096.1 (1293451..1294404)

Chromosome R - NC_032096.1Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene serine/threonine protein kinase Neighboring gene uncharacterized protein Neighboring gene ketoreductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_032096.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cdc28 provides a molecular link between Hsp90, morphogenesis, and cell cycle progression in Candida albicans. Senn H, et al. Mol Biol Cell, 2012 Jan. PMID 22090345, Free PMC Article
  2. Hyphal growth in Candida albicans requires the phosphorylation of Sec2 by the Cdc28-Ccn1/Hgc1 kinase. Bishop A, et al. EMBO J, 2010 Sep 1. PMID 20639857, Free PMC Article
  3. In Candida albicans, phosphorylation of Exo84 by Cdk1-Hgc1 is necessary for efficient hyphal extension. Caballero-Lima D, et al. Mol Biol Cell, 2014 Apr. PMID 24501427, Free PMC Article
  4. Rfa2 is specifically dephosphorylated by Pph3 in Candida albicans. Wang H, et al. Biochem J, 2013 Feb 1. PMID 23140133, Free PMC Article
  5. Cdc28-Cln3 phosphorylation of Sla1 regulates actin patch dynamics in different modes of fungal growth. Zeng G, et al. Mol Biol Cell, 2012 Sep. PMID 22787279, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cyclin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of G2/M transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cyclin-dependent serine/threonine-protein kinase
XP_713486.1
  • Cyclin-dependent protein kinase; interacts with regulatory subunit Cyb1; determination of cell morphology during the cell cycle; phosphorylated mostly by Swe1 and phosphorylation is regulated by Hsl1; 5'-UTR intron; Spider biofilm repressed

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_032096.1 Reference assembly

    Range
    1293451..1294404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_708393.1 → XP_713486.1  cyclin-dependent serine/threonine-protein kinase [Candida albicans SC5314]

    See identical proteins and their annotated locations for XP_713486.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    A0A1D8PT63, P43063, Q59V96
    UniProtKB/TrEMBL
    A0A8H6F309, C4YM45
    Conserved Domains (1) summary
    cd07835
    Location:7 → 292
    STKc_CDK1_CdkB_like; Catalytic domain of Cyclin-Dependent protein Kinase 1-like Serine/Threonine Kinases and of Plant B-type Cyclin-Dependent protein Kinase
Nucleotide Protein
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Gene LinkOut

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Other Literature Sources
Molecular Biology Databases