U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Upk1a uroplakin 1A [ Rattus norvegicus (Norway rat) ]

Gene ID: 365227, updated on 6-Jun-2024

Summary

Go to the top of the page Help
Official Symbol
Upk1aprovided by RGD
Official Full Name
uroplakin 1Aprovided by RGD
Primary source
RGD:1309849
See related
Ensembl:ENSRNOG00000024331 AllianceGenome:RGD:1309849
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in epithelial cell differentiation. Predicted to be located in apical plasma membrane and cell surface. Predicted to be integral component of membrane. Predicted to be active in apical plasma membrane urothelial plaque. Predicted to be integral component of plasma membrane. Orthologous to human UPK1A (uroplakin 1A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 19.9), Testes (RPKM 6.8) and 3 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Upk1a in Genome Data Viewer
Location:
1q21
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (94987110..94998083, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (85859672..85870147, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (89060581..89071579, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene lysine methyltransferase 2B Neighboring gene microRNA 3569 Neighboring gene zinc finger and BTB domain containing 32 Neighboring gene cytochrome c oxidase subunit 6B1 Neighboring gene ETS variant transcription factor 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Altered expression of UPIa, UPIb, UPII, and UPIIIa during urothelial carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in rats. Zupančič D, et al. Virchows Arch, 2011 May. PMID 21301865
  2. Uroplakin Ia is the urothelial receptor for uropathogenic Escherichia coli: evidence from in vitro FimH binding. Zhou G, et al. J Cell Sci, 2001 Nov. PMID 11739641
  3. Surfactant Protein A Inhibits Growth and Adherence of Uropathogenic Escherichia coli To Protect the Bladder from Infection. Hashimoto J, et al. J Immunol, 2017 Apr 1. PMID 28228557
  4. Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract. Ogawa K, et al. Am J Pathol, 1999 Oct. PMID 10514386, Free PMC Article
  5. Mammalian uroplakins. A group of highly conserved urothelial differentiation-related membrane proteins. Wu XR, et al. J Biol Chem, 1994 May 6. PMID 8175808

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. During urothelial carcinogenesis, UPII expression was the most decreased in all urothelial lesions, while UPIa, UPIb, and UPIIIa expression was differently altered in different types of lesions
    Title: Altered expression of UPIa, UPIb, UPII, and UPIIIa during urothelial carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in rats.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in apical plasma membrane urothelial plaque ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
uroplakin-1a

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108911.2 → NP_001102381.2  uroplakin-1a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A1L2C162, A0A8I5ZVR2
    Related
    ENSRNOP00000097413.1, ENSRNOT00000105462.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    94987110..94998083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269124.1 → XP_063125194.1  uroplakin-1a isoform X4

    UniProtKB/TrEMBL
    A0A1L2C162, A0A8I5ZVR2

  2. XM_063269118.1 → XP_063125188.1  uroplakin-1a isoform X2

    UniProtKB/TrEMBL
    D3ZDW5

  3. XM_063269121.1 → XP_063125191.1  uroplakin-1a isoform X2

    UniProtKB/TrEMBL
    D3ZDW5

  4. XM_039084978.2 → XP_038940906.1  uroplakin-1a isoform X5

    UniProtKB/TrEMBL
    D3ZDW5
    Conserved Domains (1) summary
    cd03156
    Location:113 → 217
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

  5. XM_063269116.1 → XP_063125186.1  uroplakin-1a isoform X1

  6. XM_063269122.1 → XP_063125192.1  uroplakin-1a isoform X3

    UniProtKB/TrEMBL
    D3ZDW5
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools