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Ak5 adenylate kinase 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 365985, updated on 11-Apr-2024

Summary

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Official Symbol
Ak5provided by RGD
Official Full Name
adenylate kinase 5provided by RGD
Primary source
RGD:1590818
See related
Ensembl:ENSRNOG00000046947 AllianceGenome:RGD:1590818
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in nucleoside diphosphate phosphorylation and nucleoside triphosphate biosynthetic process. Predicted to be located in centriolar satellite. Predicted to be active in cytosol. Orthologous to human AK5 (adenylate kinase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 166.4), Kidney (RPKM 43.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ak5 in Genome Data Viewer
Location:
2q45
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (244057240..244241372, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (241397297..241581483, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (257671772..257864385, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100974 Neighboring gene mitoguardin 1 Neighboring gene ubiquitin specific peptidase 33 Neighboring gene zinc finger, ZZ-type containing 3 Neighboring gene uncharacterized LOC134485695 Neighboring gene uncharacterized LOC120100975 Neighboring gene NHP2-like protein 1 Neighboring gene uncharacterized LOC120100977 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class K

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of a novel human adenylate kinase. cDNA cloning, expression analysis, chromosome localization and characterization of the recombinant protein. Van Rompay AR, et al. Eur J Biochem, 1999 Apr. PMID 10215863
  2. The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase. Amiri M, et al. Int J Biochem Cell Biol, 2013 May. PMID 23416111
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside diphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleoside diphosphate kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ATP metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleoside monophosphate phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
adenylate kinase isoenzyme 5
NP_001102421.1
XP_017446496.1
XP_063138379.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108951.1 → NP_001102421.1  adenylate kinase isoenzyme 5

    See identical proteins and their annotated locations for NP_001102421.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473952
    UniProtKB/TrEMBL
    A0A8I6GL77, A6HWM1, M0R7U1
    Related
    ENSRNOP00000065527.1, ENSRNOT00000072048.2
    Conserved Domains (2) summary
    TIGR01360
    Location:374 → 561
    aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
    cd01428
    Location:378 → 550
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    244057240..244241372 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017591007.3 → XP_017446496.1  adenylate kinase isoenzyme 5 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GL77

  2. XM_063282309.1 → XP_063138379.1  adenylate kinase isoenzyme 5 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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