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Galnt3 polypeptide N-acetylgalactosaminyltransferase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 366061, updated on 11-Apr-2024

Summary

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Official Symbol
Galnt3provided by RGD
Official Full Name
polypeptide N-acetylgalactosaminyltransferase 3provided by RGD
Primary source
RGD:1306443
See related
Ensembl:ENSRNOG00000005727 AllianceGenome:RGD:1306443
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium ion binding activity; manganese ion binding activity; and polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation via serine and protein O-linked glycosylation via threonine. Predicted to act upstream of or within protein O-linked glycosylation and spermatogenesis. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in Golgi apparatus. Orthologous to human GALNT3 (polypeptide N-acetylgalactosaminyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 107.5), Kidney (RPKM 99.0) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Galnt3 in Genome Data Viewer
Location:
3q21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (71150559..71187321, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (50742500..50779266, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (52174469..52212395, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene cysteine and serine rich nuclear protein 3 Neighboring gene trichohyalin-like Neighboring gene uncharacterized LOC134486371 Neighboring gene uncharacterized LOC134486372 Neighboring gene tetratricopeptide repeat domain 21B Neighboring gene ribosomal protein L7a, pseudogene 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O-glycosylation. Kato K, et al. J Biol Chem, 2006 Jul 7. PMID 16638743
  2. Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3. Wandall HH, et al. J Biol Chem, 1997 Sep 19. PMID 9295285
  3. The cell-layer- and cell-type-specific distribution of GalNAc-transferases in the ocular surface epithelia is altered during keratinization. Argüeso P, et al. Invest Ophthalmol Vis Sci, 2003 Jan. PMID 12506059
  4. Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. Kang D, et al. J Proteome Res, 2008 Aug. PMID 18570454
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC124508

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein O-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation via serine ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation via threonine ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
polypeptide N-acetylgalactosaminyltransferase 3
Names
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
NP_001015032.2
XP_006234352.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001015032.3 → NP_001015032.2  polypeptide N-acetylgalactosaminyltransferase 3

    See identical proteins and their annotated locations for NP_001015032.2

    Status: PROVISIONAL

    Source sequence(s)
    BC101886
    UniProtKB/TrEMBL
    A6HLX8, F7FMK3, Q3T1J4, Q58A69
    Related
    ENSRNOP00000007615.4, ENSRNOT00000007615.7
    Conserved Domains (2) summary
    cd02510
    Location:188 → 493
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:506 → 627
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    71150559..71187321 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234290.4 → XP_006234352.1  polypeptide N-acetylgalactosaminyltransferase 3 isoform X1

    See identical proteins and their annotated locations for XP_006234352.1

    UniProtKB/TrEMBL
    A6HLX8, F7FMK3, Q3T1J4, Q58A69
    Conserved Domains (2) summary
    cd02510
    Location:188 → 493
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:506 → 627
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
Nucleotide Protein Strain
Heading Accession and Version

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