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Xpc Xeroderma pigmentosum, complementation group C [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36697, updated on 10-May-2024

Summary

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Official Symbol
Xpcprovided by FlyBase
Official Full Name
Xeroderma pigmentosum, complementation group Cprovided by FlyBase
Primary source
FLYBASE:FBgn0004698
Locus tag
Dmel_CG8153
See related
AllianceGenome:FB:FBgn0004698
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8153; DhR4; DhXPC; Dmel\CG8153; DmXPC; Mus 210; mus(2)201; mus(2)201G1; mus(2)201[GI]; mus201[G1]; mus210; Mus210; mus212; XPC; Xpcc; XPC[DM]
Summary
Predicted to enable damaged DNA binding activity and single-stranded DNA binding activity. Involved in meiotic mismatch repair involved in reciprocal meiotic recombination. Predicted to be located in cytosol and nucleus. Predicted to be part of XPC complex and nucleotide-excision repair factor 2 complex. Predicted to be active in cytoplasm. Is expressed in head mesoderm anlage; organism; and trunk mesoderm anlage. Human ortholog(s) of this gene implicated in pancreatic cancer; serous cystadenocarcinoma; xeroderma pigmentosum; and xeroderma pigmentosum group C. Orthologous to human XPC (XPC complex subunit, DNA damage recognition and repair factor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Xpc in Genome Data Viewer
Location:
51F4-51F5; 2-74 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15311510..15318239)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11199015..11205744)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Transient receptor potential cation channel, subfamily M Neighboring gene NADH dehydrogenase (ubiquinone) 51 kDa subunit-like 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ADP ribosylation factor 6 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CSB-independent, XPC-dependent transcription-coupled repair in Drosophila. Deger N, et al. Proc Natl Acad Sci U S A, 2022 Mar 1. PMID 35217627, Free PMC Article
  2. Cloning the Drosophila homolog of the xeroderma pigmentosum complementation group C gene reveals homology between the predicted human and Drosophila polypeptides and that encoded by the yeast RAD4 gene. Henning KA, et al. Nucleic Acids Res, 1994 Feb 11. PMID 8127661, Free PMC Article
  3. [Analysis of the mutagenic and teratogenic effect of griseofulvin in the mutagen-sensitive Drosophila melanogaster line mus(2)201G1]. Isaenko OA, et al. Genetika, 1994 Jun. PMID 7958794
  4. [Radiosensitive lines of Drosophila. V. The sensitivity of mutant mus(2) 201G1 to methyl methanesulfonate and UV radiation and disordered DNA repair in UV-irradiated cells]. Luchkina LA, et al. Genetika, 1982 Apr. PMID 7200926
  5. [Radiosensitive mutants of Drosophila. VI. The effect of ultraviolet rays and methylmethane sulfonate on the viability and incidence of chromosome aberrations in the somatic cells of mutant mus(2)201G1]. Levina VV, et al. Genetika, 1984 Mar. PMID 6425117

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables damaged DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in meiotic mismatch repair involved in reciprocal meiotic recombination IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide-excision repair ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of XPC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of nucleotide-excision repair factor 2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
xeroderma pigmentosum, complementation group C
Names
CG8153-PA
CG8153-PC
CG8153-PD
Xpc-PA
Xpc-PC
Xpc-PD
mus210
mutagen-sensitive 210
xeroderma pigmentosum group C complementing factor
xeroderma pigmentosum group C-like

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    15311510..15318239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166087.2 → NP_725451.1  xeroderma pigmentosum, complementation group C, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725451.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24595
    Related
    FBpp0086505
    Conserved Domains (5) summary
    smart01032
    Location:1178 → 1252
    BHD_3; Rad4 beta-hairpin domain 3
    smart01030
    Location:1062 → 1112
    BHD_1; Rad4 beta-hairpin domain 1
    smart01031
    Location:1115 → 1170
    BHD_2; Rad4 beta-hairpin domain 2
    TIGR00605
    Location:345 → 1294
    rad4; DNA repair protein rad4
    pfam03835
    Location:925 → 1057
    Rad4; Rad4 transglutaminase-like domain

  2. NM_057513.4 → NP_476861.1  xeroderma pigmentosum, complementation group C, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476861.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24595, Q7KJI5, Q8MLA1, Q8MLA2, Q9U3Z0, Q9U3Z1, Q9V7A8
    Related
    FBpp0086506
    Conserved Domains (5) summary
    smart01032
    Location:1177 → 1251
    BHD_3; Rad4 beta-hairpin domain 3
    smart01030
    Location:1061 → 1111
    BHD_1; Rad4 beta-hairpin domain 1
    smart01031
    Location:1114 → 1169
    BHD_2; Rad4 beta-hairpin domain 2
    TIGR00605
    Location:344 → 1293
    rad4; DNA repair protein rad4
    pfam03835
    Location:924 → 1056
    Rad4; Rad4 transglutaminase-like domain

  3. NM_001259407.2 → NP_001246336.1  xeroderma pigmentosum, complementation group C, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246336.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K739, E3CTS1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K739 A0A0B4K739
Q24595.2 Q24595

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