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Arf6 ADP ribosylation factor 6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36699, updated on 26-Apr-2024

Summary

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Official Symbol
Arf6provided by FlyBase
Official Full Name
ADP ribosylation factor 6provided by FlyBase
Primary source
FLYBASE:FBgn0013750
Locus tag
Dmel_CG8156
See related
AllianceGenome:FB:FBgn0013750
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AFR51F; Arf3; ARF3; arf51f; arf51F; Arf51f; Arf51F; arf6; ARF6; ARFIII; CG8156; d-Arf6; dArf6; dARFIII; Dm Arf51F; Dmel\CG8156; EP(2)2612; LD12493; P40946
Summary
Enables enzyme activator activity. Involved in several processes, including behavioral response to ethanol; male gamete generation; and myoblast fusion. Located in cleavage furrow; cytosol; and endosome. Colocalizes with adherens junction. Is expressed in several structures, including adult insulin secreting cell of pars intercerebralis; embryonic/larval circulatory system; extended germ band embryo; head; and presumptive embryonic/larval system. Used to study alcohol use disorder. Orthologous to human ARF6 (ADP ribosylation factor 6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
51F6-51F6; 2-74 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15322501..15325490)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11210006..11212995)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Xeroderma pigmentosum, complementation group C Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. W::Neo: a novel dual-selection marker for high efficiency gene targeting in Drosophila. Zhou W, et al. PLoS One, 2012. PMID 22348139, Free PMC Article
  2. Target-selected mutant screen by TILLING in Drosophila. Winkler S, et al. Genome Res, 2005 May. PMID 15867432, Free PMC Article
  3. Characterization of class II and class III ADP-ribosylation factor genes and proteins in Drosophila melanogaster. Lee FJ, et al. J Biol Chem, 1994 Aug 26. PMID 8063793
  4. Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport. Guichard A, et al. PLoS Pathog, 2017 Sep. PMID 28945820, Free PMC Article
  5. S6 Kinase Reflects and Regulates Ethanol-Induced Sedation. Acevedo SF, et al. J Neurosci, 2015 Nov 18. PMID 26586826, Free PMC Article

See all (95) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Arf6 determines tissue architecture by stabilizing intercellular adhesion.
    Title: Arf6 determines tissue architecture by stabilizing intercellular adhesion.
  2. EGFR/ARF6 regulation of Hh signaling stimulates oncogenic Ras tumor overgrowth in Drosophila.
    Title: EGFR/ARF6 regulation of Hh signalling stimulates oncogenic Ras tumour overgrowth.
  3. We show that Arf6 functions in the adult nervous system to control ethanol-induced behavior.
    Title: Adult neuronal Arf6 controls ethanol-induced behavior with Arfaptin downstream of Rac1 and RhoGAP18B.
  4. Cindr-mediated regulation of Arf6 is a widely used mechanism in emerging epithelia.
    Title: Role for a Cindr-Arf6 axis in patterning emerging epithelia.
  5. ARF6 promotes rapid recycling of endosomal membrane stores during spermatocyte cytokinesis, which is critical for rapid cleavage furrow ingression.
    Title: Spermatocyte cytokinesis requires rapid membrane addition mediated by ARF6 on central spindle recycling endosomes.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables enzyme activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in behavioral response to ethanol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_positive_effect imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in male meiosis cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in myoblast fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neurotransmitter secretion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in response to alcohol IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle endocytosis TAS
Traceable Author Statement
more info
 PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
colocalizes_with adherens junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cleavage furrow IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ADP ribosylation factor 6
Names
ADP ribosylation factor 51F
ADP ribosylation factor III
ADP ribosylation factor at 51F
Arf6-PA
Arf6-PB
Arf6-PC
Arf6-PD
Arf6-PE
CG8156-PA
CG8156-PB
CG8156-PC
CG8156-PD
CG8156-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    15322501..15325490
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166090.2 → NP_725454.1  ADP ribosylation factor 6, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725454.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZH7, P40946, Q0E966, Q9V7B0
    Related
    FBpp0086507
    Conserved Domains (1) summary
    cl38936
    Location:1 → 174
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_166089.2 → NP_725453.1  ADP ribosylation factor 6, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725453.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZH7, P40946, Q0E966, Q9V7B0
    Related
    FBpp0086509
    Conserved Domains (1) summary
    cl38936
    Location:1 → 174
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. NM_079027.3 → NP_523751.2  ADP ribosylation factor 6, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523751.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZH7, P40946, Q0E966, Q9V7B0
    Related
    FBpp0086510
    Conserved Domains (1) summary
    cl38936
    Location:1 → 174
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. NM_166088.2 → NP_725452.1  ADP ribosylation factor 6, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725452.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZH7, P40946, Q0E966, Q9V7B0
    Related
    FBpp0086508
    Conserved Domains (1) summary
    cl38936
    Location:1 → 174
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  5. NM_166091.2 → NP_725455.1  ADP ribosylation factor 6, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725455.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZH7, P40946, Q0E966, Q9V7B0
    Related
    FBpp0086511
    Conserved Domains (1) summary
    cl38936
    Location:1 → 174
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40946.3 P40946

Gene LinkOut

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