Chst2 carbohydrate sulfotransferase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Chst2provided by RGD
Official Full Name: carbohydrate sulfotransferase 2provided by RGD
Primary source: RGD:1306988
See related: Ensembl:ENSRNOG00000047734 AllianceGenome:RGD:1306988
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable N-acetylglucosamine 6-O-sulfotransferase activity. Predicted to be involved in N-acetylglucosamine metabolic process; positive regulation of leukocyte tethering or rolling; and sulfur compound metabolic process. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in trans-Golgi network. Orthologous to human CHST2 (carbohydrate sulfotransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 40.2), Kidney (RPKM 28.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q31

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (104839716..104845961, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (95960067..95966312, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (103186759..103190612, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Chst2 (e-PCR), detects polymorphism
- UniSTS:527288

RH131963 (e-PCR)
- UniSTS:215246

RH139309 (e-PCR)
- UniSTS:221395

RH143193 (e-PCR)
- UniSTS:232440

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N-acetylglucosamine 6-O-sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acetylglucosamine 6-O-sulfotransferase activity	ISO Inferred from Sequence Orthology more info
enables sulfotransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in N-acetylglucosamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in N-acetylglucosamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of leukocyte tethering or rolling	ISO Inferred from Sequence Orthology more info
involved_in sulfur compound metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sulfur compound metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: carbohydrate sulfotransferase 2

Names: carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2

NP_001385823.1

EC 2.8.2.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398894.1 → NP_001385823.1 carbohydrate sulfotransferase 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

M0R868

Related

ENSRNOP00000065660.1, ENSRNOT00000075305.2

Conserved Domains (1) summary

cl21551
Location:311 → 507

Sulfotransfer_3; Sulfotransferase family