U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dgkk diacylglycerol kinase kappa [ Rattus norvegicus (Norway rat) ]

Gene ID: 367745, updated on 11-Apr-2024

Summary

Official Symbol
Dgkkprovided by RGD
Official Full Name
diacylglycerol kinase kappaprovided by RGD
Primary source
RGD:1561510
See related
Ensembl:ENSRNOG00000039323 AllianceGenome:RGD:1561510
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561510
Summary
Predicted to enable diacylglycerol kinase activity. Predicted to be involved in several processes, including diacylglycerol metabolic process; lipid phosphorylation; and response to oxidative stress. Predicted to be located in plasma membrane. Orthologous to human DGKK (diacylglycerol kinase kappa). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 19.0) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Dgkk in Genome Data Viewer
Location:
Xq12
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (18253849..18385805, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (15581991..15713814, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (16441318..16526046, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene A-kinase anchoring protein 4 Neighboring gene cyclin B3 Neighboring gene cleavage and polyadenylation specific factor 4, pseudogene 1 Neighboring gene shroom family member 4

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP-dependent diacylglycerol kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in diacylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in diacylglycerol metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphatidic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
diacylglycerol kinase kappa

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    18253849..18385805 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063280457.1XP_063136527.1  diacylglycerol kinase kappa isoform X2

  2. XM_039100305.2XP_038956233.1  diacylglycerol kinase kappa isoform X1

    UniProtKB/TrEMBL
    F1LZW2
    Related
    ENSRNOP00000056998.4
    Conserved Domains (6) summary
    smart00045
    Location:9711128
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:605727
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd13274
    Location:329423
    PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
    pfam05887
    Location:79148
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    cd20800
    Location:437494
    C1_DGK_typeII_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type II diacylglycerol kinases
    cd20852
    Location:511564
    C1_DGK_typeII_rpt2; second protein kinase C conserved region 1 (C1 domain) found in type II diacylglycerol kinases