U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mbpb myelin basic protein b [ Danio rerio (zebrafish) ]

Gene ID: 368319, updated on 27-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
mbpbprovided by ZNC
Official Full Name
myelin basic protein bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030429-21
See related
Ensembl:ENSDARG00000089413 AllianceGenome:ZFIN:ZDB-GENE-030429-21
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sb:cb183; wu:fb71b08; si:dkey-241k19.2
Summary
This gene encodes the classic myelin basic protein, a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. In humans (see PubMed ID 7504278), related transcripts found in bone marrow and the immune system arise from a longer form of the gene (referred to as Golli-MBP), which includes additional exons upstream of the exons of classic myelin basic protein. Similar to human, the zebrafish gene is characterized by alternate transcription start sites and splicing, although the full-length nature of all has yet to be determined. [provided by RefSeq, Sep 2012]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 16
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (6803324..6849800, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (6862646..6909122, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 407 Neighboring gene zinc finger protein 236 Neighboring gene rho/rac guanine nucleotide exchange factor (GEF) 2 Neighboring gene phosphomevalonate kinase

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Molecular evolution of myelin basic protein, an abundant structural myelin component. Nawaz S, et al. Glia, 2013 Aug. PMID 24040667
  2. The 3'UTRs of Myelin Basic Protein mRNAs Regulate Transport, Local Translation and Sensitivity to Neuronal Activity in Zebrafish. Torvund-Jensen J, et al. Front Mol Neurosci, 2018. PMID 29946237, Free PMC Article
  3. yippee like 3 (ypel3) is a novel gene required for myelinating and perineurial glia development. Blanco-Sánchez B, et al. PLoS Genet, 2020 Jun. PMID 32544203, Free PMC Article
  4. Exosc2 deficiency leads to developmental disorders by causing a nucleotide pool imbalance in zebrafish. Yatsuka H, et al. Biochem Biophys Res Commun, 2020 Dec 17. PMID 33333712
  5. EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia. Boczonadi V, et al. Nat Commun, 2014 Jul 3. PMID 24989451, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables structural constituent of myelin sheath IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in myelin sheath IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
myelin basic protein b; myelin basic protein
Names
Golli

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271459.1 → NP_001258388.1  myelin basic protein b isoform 2

    See identical proteins and their annotated locations for NP_001258388.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains three exons unique to Golli-MBP and exon 1 of the classic myelin basic protein. It encodes a Golli-MBP isoform (2).
    Source sequence(s)
    AL845419, CB354061, CU459091
    UniProtKB/TrEMBL
    A0A8M1P3U7, E7EYA2
    Related
    ENSDARP00000124557.1, ENSDART00000149778.2

  2. NM_001271460.1 → NP_001258389.1  myelin basic protein b isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes a classic myelin basic protein isoform (1).
    Source sequence(s)
    CU459091, EH585066
    UniProtKB/TrEMBL
    A0A8M1NZT7, F8W4C1
    Related
    ENSDARP00000124242.1, ENSDART00000149570.2
    Conserved Domains (1) summary
    pfam01669
    Location:1 → 121
    Myelin_MBP; Myelin basic protein

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    6803324..6849800 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005157835.2 → XP_005157892.1  myelin basic protein isoform X1

    See identical proteins and their annotated locations for XP_005157892.1

    UniProtKB/TrEMBL
    A0A8M2B444

RNA

  1. XR_001795957.1 RNA Sequence

  2. XR_001795955.1 RNA Sequence

  3. XR_001795956.2 RNA Sequence

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394952.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    7216..24089 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools