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GstE7 Glutathione S transferase E7 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37112, updated on 10-May-2024

Summary

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Official Symbol
GstE7provided by FlyBase
Official Full Name
Glutathione S transferase E7provided by FlyBase
Primary source
FLYBASE:FBgn0063493
Locus tag
Dmel_CG17531
See related
AllianceGenome:FB:FBgn0063493
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17531; Dmel\CG17531; DmGSTE7; E7; GST-E7; gste7; gstE7; GSTE7
Summary
Enables glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be located in cytoplasm. Is expressed in anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See GstE7 in Genome Data Viewer
Location:
55C7-55C7; 2-85 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18406924..18407688)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14294429..14295193)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Glutathione S transferase E5 Neighboring gene Glutathione S transferase E6 Neighboring gene Glutathione S transferase E8 Neighboring gene Glutathione S transferase E9 Neighboring gene immune deficiency

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression of glutathione transferase E7 in Drosophila differentially impacts toxicity of organic isothiocyanates in males and females. Mazari AM, et al. PLoS One, 2014. PMID 25329882, Free PMC Article
  2. Data on the expression of GSTE1 and GSTE7 in Drosophila chemosensory organs after isothiocyanate exposure. Fraichard S, et al. Data Brief, 2018 Oct. PMID 30148193, Free PMC Article
  3. Drosophila GSTs display outstanding catalytic efficiencies with the environmental pollutants 2,4,6-trinitrotoluene and 2,4-dinitrotoluene. Mazari AMA, et al. Biochem Biophys Rep, 2016 Mar. PMID 28955816, Free PMC Article
  4. Comparison of epsilon- and delta-class glutathione S-transferases: the crystal structures of the glutathione S-transferases DmGSTE6 and DmGSTE7 from Drosophila melanogaster. Scian M, et al. Acta Crystallogr D Biol Crystallogr, 2015 Oct. PMID 26457432, Free PMC Article
  5. Glutathione transferases immobilized on nanoporous alumina: flow system kinetics, screening, and stability. Kjellander M, et al. Anal Biochem, 2014 Feb 1. PMID 24157647

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The structures of two epsilon-class glutathione S-transferases from Drosophila, GSTE6 and GSTE7, are reported at 2.1 and 1.5 A resolution.
    Title: Comparison of epsilon- and delta-class glutathione S-transferases: the crystal structures of the glutathione S-transferases DmGSTE6 and DmGSTE7 from Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables glutathione peroxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutathione metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
glutathione S transferase E7
Names
CG17531-PA
GstE7-PA
glutathione S-transferase
glutathione transferase E7
NP_611329.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    18406924..18407688
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137485.4 → NP_611329.1  glutathione S transferase E7 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611329.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZB72, Q8MR33
    Related
    FBpp0085856
    Conserved Domains (3) summary
    cd03177
    Location:91 → 209
    GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
    COG0625
    Location:4 → 196
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cd03045
    Location:4 → 77
    GST_N_Delta_Epsilon; GST_N family, Class Delta and Epsilon subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1ZB72 A1ZB72
Q8MR33 Q8MR33

Gene LinkOut

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