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Prp19 Pre-RNA processing factor 19 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37123, updated on 28-Oct-2021

Summary

Official Symbol
Prp19provided by FlyBase
Official Full Name
Pre-RNA processing factor 19provided by FlyBase
Primary source
FLYBASE:FBgn0261119
Locus tag
Dmel_CG5519
Gene type
protein coding
RNA name
Pre-RNA processing factor 19
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD02793; CG5519; Dmel\CG5519; dPrp19; EC2-11; Gbp; GPB; l(2)07838; prp19; PRP19
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Genomic context

See Prp19 in Genome Data Viewer
Location:
55C9-55D2; 2-85 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18447361..18451041, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14334866..14338546, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class O Neighboring gene TRPL translocation defect 14 Neighboring gene scruin like at the midline Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene roswell Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
involved_in mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
PubMed 
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of Prp19 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Prp19 complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of U2-type catalytic step 1 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of catalytic step 2 spliceosome HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of precatalytic spliceosome HDA PubMed 
part_of spliceosomal complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
Pre-RNA processing factor 19
Names
CG5519-PA
GTP-binding regulatory protein beta chain
NM 079059.2
Prp19-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    18447361..18451041 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079059.3NP_523783.1  Pre-RNA processing factor 19 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523783.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KLW9
    Related
    FBpp0085902, FBtr0086723
    Conserved Domains (5) summary
    smart00504
    Location:268
    Ubox; Modified RING finger domain
    COG2319
    Location:225505
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:210503
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08606
    Location:69132
    Prp19; Prp19/Pso4-like
    sd00039
    Location:269305
    7WD40; WD40 repeat [structural motif]
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