Pepck2 Phosphoenolpyruvate carboxykinase 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pepck2provided by FlyBase
Official Full Name: Phosphoenolpyruvate carboxykinase 2provided by FlyBase
Primary source: FLYBASE:FBgn0034356
Locus tag: Dmel_CG10924
See related: AllianceGenome:FB:FBgn0034356
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10924; Dmel\CG10924; pepck; Pepck; PEPCK; pepck2
Summary: Predicted to enable manganese ion binding activity and phosphoenolpyruvate carboxykinase (GTP) activity. Predicted to be involved in several processes, including cellular response to glucose stimulus; gluconeogenesis; and monocarboxylic acid metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including embryonic/larval midgut primordium; extended germ band embryo; gastrula embryo; posterior ectoderm anlage; and yolk. Orthologous to human PCK2 (phosphoenolpyruvate carboxykinase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (18527430..18535749)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (14414935..14423254)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoenolpyruvate carboxykinase (GTP) activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoenolpyruvate carboxykinase (GTP) activity	IEA Inferred from Electronic Annotation more info
enables phosphoenolpyruvate carboxykinase (GTP) activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphoenolpyruvate carboxykinase activity	IEA Inferred from Electronic Annotation more info
enables purine nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to dexamethasone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to glucose stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to insulin stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in gluconeogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycerol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycerol biosynthetic process from pyruvate	IBA Inferred from Biological aspect of Ancestor more info
involved_in oxaloacetate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in propionate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in trehalose biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in triglyceride biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

Names: CG10924-PA; CG10924-PB; Pepck2-PA; Pepck2-PB; pepck isogene; phosphoenol-pyruvate carboxykinase; predicted phosphoenolpyruvate carboxykinase

NP_001097367.1

NP_611341.1

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The following sections contain reference sequences that belong to a specific genome build. Explain