Format

Send to:

Choose Destination

TBX5 T-box 5 [ Gallus gallus (chicken) ]

Gene ID: 373988, updated on 22-Aug-2021

Summary

Symbol
TBX5provided by CGNC
Full Name
T-box 5provided by CGNC
Primary source
CGNC:6251
See related
Ensembl:ENSGALG00000008253
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TBX5 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
10
Annotation release Status Assembly Chr Location
105 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 15 NC_052546.1 (12317331..12358318)
105 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.1) 15 NC_052587.1 (12329351..12369697)
104 previous assembly GRCg6a (GCF_000002315.5) 15 NC_006102.5 (12598201..12638588)
103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) 15 NC_006102.4 (12380768..12421152)

Chromosome 15 - NC_052546.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121106871 Neighboring gene T-box 3 Neighboring gene uncharacterized LOC107054672 Neighboring gene uncharacterized LOC107054670 Neighboring gene RNA binding motif protein 19

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
enables LIM domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in animal organ development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in atrial septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in atrioventricular bundle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in atrioventricular node cell development IEA
Inferred from Electronic Annotation
more info
 
involved_in atrioventricular node cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
involved_in atrioventricular valve morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in bundle of His cell to Purkinje myocyte communication by electrical coupling IEA
Inferred from Electronic Annotation
more info
 
involved_in cardiac left ventricle formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cardiac left ventricle formation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-cell signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell-cell signaling involved in cardiac conduction IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic forelimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic forelimb morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in embryonic limb morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in endocardial cushion development IEA
Inferred from Electronic Annotation
more info
 
involved_in heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in heart development TAS
Traceable Author Statement
more info
PubMed 
involved_in hindlimb morphogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in limb bud formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in limb development TAS
Traceable Author Statement
more info
PubMed 
involved_in lung development IEA
Inferred from Electronic Annotation
more info
 
involved_in morphogenesis of an epithelium IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cardiac muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in pattern specification process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in pericardium development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cardiac conduction IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cardiac muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cardioblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of gap junction assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of secondary heart field cardioblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of atrial cardiac muscle cell membrane depolarization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to retinoic acid TAS
Traceable Author Statement
more info
PubMed 
involved_in ventricular septum development IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in actin filament IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of protein-DNA complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of protein-containing complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in stress fiber IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
T-box transcription factor TBX5
Names
T-box protein 5

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204173.1NP_989504.1  T-box transcription factor TBX5

    See identical proteins and their annotated locations for NP_989504.1

    Status: PROVISIONAL

    Source sequence(s)
    AF069396
    UniProtKB/Swiss-Prot
    Q9PWE8
    UniProtKB/TrEMBL
    R9PXM9
    Related
    ENSGALP00000013419.5, ENSGALT00000013434.6
    Conserved Domains (1) summary
    cd00182
    Location:53241
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052546.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    12317331..12358318
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015294831.3XP_015150317.1  T-box transcription factor TBX5 isoform X2

    Conserved Domains (1) summary
    cd00182
    Location:69257
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
  2. XM_015294830.3XP_015150316.1  T-box transcription factor TBX5 isoform X1

    Conserved Domains (1) summary
    cd00182
    Location:77265
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052587.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    12329351..12369697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center