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HSD11B1L hydroxysteroid 11-beta dehydrogenase 1 like [ Homo sapiens (human) ]

Gene ID: 374875, updated on 23-Nov-2021

Summary

Official Symbol
HSD11B1Lprovided by HGNC
Official Full Name
hydroxysteroid 11-beta dehydrogenase 1 likeprovided by HGNC
Primary source
HGNC:HGNC:30419
See related
Ensembl:ENSG00000167733
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSD3; HSD1L; 11-DH3; SCDR10; SCDR10B; SDR26C2; 11-beta-HSD3
Summary
This gene is a member of the hydroxysteroid dehydrogenase family. The encoded protein is similar to an enzyme that catalyzes the interconversion of inactive to active glucocorticoids (e.g. cortisone). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]
Expression
Broad expression in brain (RPKM 7.1), testis (RPKM 2.5) and 23 other tissues See more
Orthologs
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Genomic context

See HSD11B1L in Genome Data Viewer
Location:
19p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (5681027..5688522)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (5681038..5688533)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985320 Neighboring gene mitochondrial contact site and cristae organizing system subunit 13 Neighboring gene ribosomal protein L36 Neighboring gene lon peptidase 1, mitochondrial Neighboring gene cation channel sperm associated auxiliary subunit delta

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: RPL36

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
hydroxysteroid 11-beta-dehydrogenase 1-like protein
Names
11-beta-hydroxysteroid dehydrogenase type 3
short chain dehydrogenase/reductase 10
short chain dehydrogenase/reductase family 26C member 2
NP_001254797.1
NP_001254798.1
NP_001254799.1
NP_001254800.1
NP_940935.1
NP_941993.1
NP_941994.1
NP_941995.1
NP_941996.1
NP_941997.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267868.2NP_001254797.1  hydroxysteroid 11-beta-dehydrogenase 1-like protein isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (g) represents the longest transcript and the longest protein (isoform g).
    Source sequence(s)
    AC011499, AI871311, AK308206
    Consensus CDS
    CCDS74266.1
    UniProtKB/TrEMBL
    A0A087WWR3
    Related
    ENSP00000480443.1, ENST00000616276.4
    Conserved Domains (3) summary
    PRK08251
    Location:78302
    PRK08251; short chain dehydrogenase; Provisional
    pfam13900
    Location:326
    GVQW; Putative domain of unknown function
    cl21454
    Location:74302
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. NM_001267869.2NP_001254798.1  hydroxysteroid 11-beta-dehydrogenase 1-like protein isoform d

    See identical proteins and their annotated locations for NP_001254798.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (j) has multiple differences in the coding region, and initiates translation at an alternate downstream in-frame start codon, compared to variant g. The encoded isoform (d) is shorter than isoform g. Variants d and j encode the same protein.
    Source sequence(s)
    AC011499, BC094798
    Consensus CDS
    CCDS58642.1
    UniProtKB/Swiss-Prot
    Q7Z5J1
    Related
    ENSP00000464454.1, ENST00000581893.5
    Conserved Domains (1) summary
    cl25409
    Location:1121
    SDR; Short-chain dehydrogenases/reductases (SDR)
  3. NM_001267870.2NP_001254799.1  hydroxysteroid 11-beta-dehydrogenase 1-like protein isoform h precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (h) has multiple differences in the coding region, one of which results in initiation of translation at a downstream in-frame start codon, compared to variant g. An additional difference results in a frameshift. The encoded protein (isoform h) has a distinct C-terminus and is shorter than isoform g.
    Source sequence(s)
    AY313894, CX865680, DA343367
    UniProtKB/Swiss-Prot
    Q7Z5J1
    Related
    ENSP00000463187.1, ENST00000579559.1
  4. NM_001267871.2NP_001254800.1  hydroxysteroid 11-beta-dehydrogenase 1-like protein isoform i precursor

    See identical proteins and their annotated locations for NP_001254800.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (i) has multiple differences in the coding region, one of which results in initiation of translation at a downstream in-frame start codon, compared to variant g. An additional difference results in a frameshift. The encoded protein (isoform i) has a distinct C-terminus and is shorter than isoform g.
    Source sequence(s)
    AY313896
    Consensus CDS
    CCDS58641.1
    UniProtKB/Swiss-Prot
    Q7Z5J1
    Related
    ENSP00000463073.1, ENST00000577917.5
    Conserved Domains (1) summary
    cl21454
    Location:25148
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  5. NM_198533.3NP_940935.1  hydroxysteroid 11-beta-dehydrogenase 1-like protein isoform e precursor

    See identical proteins and their annotated locations for NP_940935.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (e) lacks an exon and a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant g. This variant (e) also uses an alternate splice site in the 3' coding region, which results in a frameshift. The encoded protein (isoform e) has a distinct C-terminus and is shorter than isoform g.
    Source sequence(s)
    AY313894, DA343367
    Consensus CDS
    CCDS45931.1
    UniProtKB/Swiss-Prot
    Q7Z5J1
    Related
    ENSP00000407154.2, ENST00000423665.6
    Conserved Domains (2) summary
    PRK06138
    Location:27247
    PRK06138; short chain dehydrogenase; Provisional
    cl21454
    Location:27229
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  6. NM_198704.3NP_941993.1  hydroxysteroid 11-beta-dehydrogenase 1-like protein isoform f

    See identical proteins and their annotated locations for NP_941993.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (f) has multiple differences in the coding region, one of which results in initiation of translation at a downstream in-frame start codon, compared to variant g. An additional difference results in a frameshift. The encoded protein (isoform f) has a distinct C-terminus and is shorter than isoform g.
    Source sequence(s)
    AY313895
    Consensus CDS
    CCDS45932.1
    UniProtKB/Swiss-Prot
    Q7Z5J1
    Related
    ENSP00000398955.2, ENST00000411793.6
    Conserved Domains (1) summary
    cl21454
    Location:195
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  7. NM_198705.3NP_941994.1  hydroxysteroid 11-beta-dehydrogenase 1-like protein isoform a precursor

    See identical proteins and their annotated locations for NP_941994.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) has multiple differences in the coding region, one of which results in initiation of translation at a downstream in-frame start codon, compared to variant g. The encoded protein (isoform a) is shorter than isoform g.
    Source sequence(s)
    AY268351
    Consensus CDS
    CCDS12144.1
    UniProtKB/Swiss-Prot
    Q7Z5J1
    Related
    ENSP00000301382.4, ENST00000301382.8
    Conserved Domains (1) summary
    cl21454
    Location:25174
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  8. NM_198706.3NP_941995.1  hydroxysteroid 11-beta-dehydrogenase 1-like protein isoform b precursor

    See identical proteins and their annotated locations for NP_941995.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) lacks an exon and a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant g. The encoded isoform (b) is shorter than isoform g.
    Source sequence(s)
    AY268352, DA343367
    Consensus CDS
    CCDS12145.1
    UniProtKB/Swiss-Prot
    Q7Z5J1
    Related
    ENSP00000340436.2, ENST00000339423.7
    Conserved Domains (2) summary
    PRK08251
    Location:31255
    PRK08251; short chain dehydrogenase; Provisional
    cl21454
    Location:27255
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  9. NM_198707.3NP_941996.1  hydroxysteroid 11-beta-dehydrogenase 1-like protein isoform c

    See identical proteins and their annotated locations for NP_941996.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (c) lacks two exons and a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter than isoform g.
    Source sequence(s)
    AY268353, DA343367
    Consensus CDS
    CCDS12146.1
    UniProtKB/Swiss-Prot
    Q7Z5J1
    Related
    ENSP00000343451.2, ENST00000342970.6
    Conserved Domains (1) summary
    cl21454
    Location:1168
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  10. NM_198708.3NP_941997.1  hydroxysteroid 11-beta-dehydrogenase 1-like protein isoform d

    See identical proteins and their annotated locations for NP_941997.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (d) has multiple differences in the coding region, and initiates translation at an alternate downstream in-frame start codon, compared to variant g. The encoded isoform (d) is shorter than isoform g. Variants d and j encode the same protein.
    Source sequence(s)
    AY268354, DA343367
    Consensus CDS
    CCDS58642.1
    UniProtKB/Swiss-Prot
    Q7Z5J1
    Conserved Domains (1) summary
    cl25409
    Location:1121
    SDR; Short-chain dehydrogenases/reductases (SDR)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    5681027..5688522
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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