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fabp fatty acid binding protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3772232, updated on 10-May-2024

Summary

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Official Symbol
fabpprovided by FlyBase
Official Full Name
fatty acid binding proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0037913
Locus tag
Dmel_CG6783
See related
AllianceGenome:FB:FBgn0037913
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Posey234; anon-WO0140519.12; BcDNA:RH06221; BcDNA:RH46282; BcDNA:RH49003; BcDNA:SD12036; CG31305; CG31305-PI; CG6783; CT21061; dFabp; dFABP; Dmel\CG6783; Fabp; FABP
Summary
Predicted to enable fatty acid binding activity. Involved in long-term memory. Located in cytosol and nucleoplasm. Is expressed in adult head; adult heart; and embryonic/larval lateral glial cell. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1G; hypertension; and type 2 diabetes mellitus. Orthologous to several human genes including FABP3 (fatty acid binding protein 3) and FABP4 (fatty acid binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See fabp in Genome Data Viewer
Location:
86E10-86E10; 3-51 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11559896..11567054, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7385618..7392776, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene scheggia Neighboring gene Multidrug resistance protein 4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Roles of Drosophila fatty acid-binding protein in development and behavior. Jang S, et al. Biochem Biophys Res Commun, 2022 Apr 9. PMID 35176630
  2. The ligand-mediated affinity of brain-type fatty acid-binding protein for membranes determines the directionality of lipophilic cargo transport. Cheng YY, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2019 Dec. PMID 31404652
  3. Amyloid-β induces sleep fragmentation that is rescued by fatty acid binding proteins in Drosophila. Gerstner JR, et al. J Neurosci Res, 2017 Aug. PMID 27320125, Free PMC Article
  4. Cytoplasmic to nuclear localization of fatty-acid binding protein correlates with specific forms of long-term memory in Drosophila. Gerstner JR, et al. Commun Integr Biol, 2011 Sep. PMID 22046481, Free PMC Article
  5. Fatty acid binding protein is required for chitin biosynthesis in the wing of Drosophila melanogaster. Chen J, et al. Insect Biochem Mol Biol, 2022 Oct. PMID 36165873

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Roles of Drosophila fatty acid-binding protein in development and behavior.
    Title: Roles of Drosophila fatty acid-binding protein in development and behavior.
  2. This study showed that the unliganded archetypal Drosophila brain-type fatty acid-binding protein (dFABP) possesses a stronger binding affinity than its liganded counterpart for empty nanodiscs. The crystallographic temperature factor data suggest enhanced alphaII helix dynamics upon Long-chain fatty acids binding.
    Title: The ligand-mediated affinity of brain-type fatty acid-binding protein for membranes determines the directionality of lipophilic cargo transport.
  3. These studies suggest that alterations in Fabp levels and/or activity may be associated with sleep disturbances in Alzheimer disease.
    Title: Amyloid-β induces sleep fragmentation that is rescued by fatty acid binding proteins in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chitin-based cuticle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
fatty acid binding protein
Names
CG6783-PA
CG6783-PB
CG6783-PC
fabp-PA
fabp-PB
fabp-PC
fatty acid bindin protein
fatty-acid binding protein
fatty-acid-binding protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    11559896..11567054 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001032008.2 → NP_001027179.1  fatty acid binding protein, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027179.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8INK3
    Conserved Domains (1) summary
    pfam00061
    Location:7 → 107
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

  2. NM_001032009.2 → NP_001027180.1  fatty acid binding protein, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027180.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IGA2, Q9VGM2
    Conserved Domains (1) summary
    cd19852
    Location:2 → 129
    FABP_pancrustacea; fatty acid-binding protein similar to Locusta migratoria FABP (Lm-FABP)

  3. NM_001032010.2 → NP_001027181.1  fatty acid binding protein, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027181.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8INK2
    Conserved Domains (1) summary
    pfam00061
    Location:5 → 115
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
5GGE_A.1
5GKB_A.1
Q8IGA2 Q8IGA2
Q8INK2 Q8INK2
Q8INK3 Q8INK3
Q9VGM2 Q9VGM2

Gene LinkOut

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