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CG5554 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37775, updated on 10-May-2024

Summary

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Official Symbol
CG5554provided by FlyBase
Primary source
FLYBASE:FBgn0034914
Locus tag
Dmel_CG5554
See related
AllianceGenome:FB:FBgn0034914
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG5554
Summary
Predicted to enable disulfide oxidoreductase activity. Located in endomembrane system. Is expressed in adult head and adult heart. Orthologous to several human genes including TMX1 (thioredoxin related transmembrane protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See CG5554 in Genome Data Viewer
Location:
60A3-60A3; 2-105 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23845001..23847024)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19732524..19734547)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene shutdown Neighboring gene Synaptosomal-associated protein 29kDa Neighboring gene yantar Neighboring gene antisense RNA:CR45928 Neighboring gene eukaryotic translation initiation factor 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The thioredoxin-like fold: hidden domains in protein disulfide isomerases and other chaperone proteins. Clissold PM, et al. Bioessays, 2003 Jun. PMID 12766950
  2. Drosophila TRF2 and TAF9 regulate lipid droplet size and phospholipid fatty acid composition. Fan W, et al. PLoS Genet, 2017 Mar. PMID 28273089, Free PMC Article
  3. Profiling of the muscle-specific dystroglycan interactome reveals the role of Hippo signaling in muscular dystrophy and age-dependent muscle atrophy. Yatsenko AS, et al. BMC Med, 2020 Jan 21. PMID 31959160, Free PMC Article
  4. Stem Cell-Intrinsic, Seven-up-Triggered Temporal Factor Gradients Diversify Intermediate Neural Progenitors. Ren Q, et al. Curr Biol, 2017 May 8. PMID 28434858
  5. An anti-inflammatory transcriptional cascade conserved from flies to humans. Pavlidaki A, et al. Cell Rep, 2022 Oct 18. PMID 36261018

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables disulfide oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-disulfide reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endomembrane system HDA PubMed 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG5554-PA
CG5554-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23845001..23847024
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299855.1 → NP_001286784.1  uncharacterized protein Dmel_CG5554, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286784.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LHC9
    Conserved Domains (1) summary
    cd02994
    Location:36 → 136
    PDI_a_TMX; PDIa family, TMX subfamily; composed of proteins similar to the TRX-related human transmembrane protein, TMX. TMX is a type I integral membrane protein; the N-terminal redox active TRX domain is present in the endoplasmic reticulum (ER) lumen while the ...

  2. NM_137994.3 → NP_611838.1  uncharacterized protein Dmel_CG5554, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611838.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W1I7
    Related
    FBpp0072035
    Conserved Domains (1) summary
    cd02994
    Location:36 → 136
    PDI_a_TMX; PDIa family, TMX subfamily; composed of proteins similar to the TRX-related human transmembrane protein, TMX. TMX is a type I integral membrane protein; the N-terminal redox active TRX domain is present in the endoplasmic reticulum (ER) lumen while the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LHC9 A0A0B4LHC9
Q9W1I7 Q9W1I7

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