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Lrrc24 leucine rich repeat containing 24 [ Mus musculus (house mouse) ]

Gene ID: 378937, updated on 5-Mar-2024

Summary

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Official Symbol
Lrrc24provided by MGI
Official Full Name
leucine rich repeat containing 24provided by MGI
Primary source
MGI:MGI:3605040
See related
Ensembl:ENSMUSG00000033707 AllianceGenome:MGI:3605040
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6430402H13Rik
Summary
Acts upstream of or within positive regulation of synapse assembly. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. Is expressed in central nervous system; dorsal root ganglion; and liver. Orthologous to human LRRC24 (leucine rich repeat containing 24). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 13.7), cerebellum adult (RPKM 13.2) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 D3; 15 36.28 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76599476..76606373, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76715276..76722173, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7385 Neighboring gene major facilitator superfamily domain containing 3 Neighboring gene RecQ protein-like 4 Neighboring gene RIKEN cDNA C030006K11 gene Neighboring gene leucine rich repeat containing 14 Neighboring gene Rho GTPase activating protein 39 Neighboring gene STARR-positive B cell enhancer mm9_chr15:76600695-76600996 Neighboring gene predicted gene, 17271 Neighboring gene STARR-positive B cell enhancer ABC_E8939 Neighboring gene STARR-seq mESC enhancer starr_39062 Neighboring gene predicted gene, 41350

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The intergenic region between the Mouse Recql4 and Lrrc14 genes functions as an evolutionary conserved bidirectional promoter. Uwanogho DA, et al. Gene, 2010 Jan 1. PMID 19720120
  2. Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo. Homma S, et al. Gene Expr Patterns, 2009 Jan. PMID 18848646
  3. Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Um JW, et al. Cell Rep, 2014 Mar 27. PMID 24613359, Free PMC Article
  4. Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. Gu Z, et al. PLoS One, 2015. PMID 25826454, Free PMC Article
  5. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of synapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198119.2 → NP_932787.1  leucine-rich repeat-containing protein 24 precursor

    See identical proteins and their annotated locations for NP_932787.1

    Status: PROVISIONAL

    Source sequence(s)
    AK078176
    Consensus CDS
    CCDS27590.1
    UniProtKB/Swiss-Prot
    Q14AD4, Q8BHA1
    Related
    ENSMUSP00000061906.5, ENSMUST00000049956.5
    Conserved Domains (7) summary
    smart00082
    Location:212 → 265
    LRRCT; Leucine rich repeat C-terminal domain
    smart00410
    Location:274 → 370
    IG_like; Immunoglobulin like
    cd00116
    Location:60 → 166
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:61 → 83
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:131 → 171
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:84 → 142
    LRR_8; Leucine rich repeat
    cl11960
    Location:267 → 361
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    76599476..76606373 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BHA1.1 GenPept UniProtKB/Swiss-Prot:Q8BHA1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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