key kenny [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: keyprovided by FlyBase
Official Full Name: kennyprovided by FlyBase
Primary source: FLYBASE:FBgn0041205
Locus tag: Dmel_CG16910
See related: AllianceGenome:FB:FBgn0041205
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG16910; dIKK; dIKK-gamma; dIKKgamma; Dmel\CG16910; DmIKK-gamma; dmIKKgamma; Dmikkgamma; DmIKKgamma; IKK; IKK-gamma; IKKg; IKKG; IKKgamma; Ikkgammabeta; IKK[[gamma]]; Kenny; Key; KEY
Summary: Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity. Involved in several processes, including defense response to other organism; positive regulation of cellular biosynthetic process; and positive regulation of defense response to virus by host. Located in cytoplasm and nucleus. Is expressed in adult Malpighian tubule and organism. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Bloch-Sulzberger syndrome; Paget's disease of bone; amyotrophic lateral sclerosis (multiple); and glaucoma (multiple). Orthologous to human IKBKG (inhibitor of nuclear factor kappa B kinase regulatory subunit gamma) and OPTN (optineurin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 60E1-60E1; 2-107 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (24785514..24787411, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (20673037..20674934, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Wolbachia-induced expression of kenny gene in testes affects male fertility in Drosophila melanogaster.
Title: Wolbachia-induced expression of kenny gene in testes affects male fertility in Drosophila melanogaster.
Drosophila Kenny is a selective autophagy receptor that mediates the degradation of the IkappaB kinase complex. Selective autophagic degradation of the IkappaB kinase complex prevents constitutive activation of the immune deficiency pathway in response to commensal microbiota. We show that autophagy-deficient flies have a systemic innate immune response that promotes a hyperplasia phenotype in the midgut.
Title: Kenny mediates selective autophagic degradation of the IKK complex to control innate immune responses.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables K63-linked polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables K63-linked polyubiquitin modification-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	HMP more info	PubMed
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidoglycan recognition protein signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidoglycan recognition protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of antibacterial peptide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of defense response to virus by host	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of innate immune response	HMP more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: kenny

Names: CG16910-PA; CG16910-PB; kenney; key-PA; key-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

24785514..24787411 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079132.4 → NP_523856.2 kenny, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523856.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9GYV5, Q9W105

UniProtKB/TrEMBL

B6IDS7

Related

FBpp0072333

Conserved Domains (2) summary

cd09803
Location:230 → 313

UBAN; polyubiquitin binding domain of NEMO and related proteins

cl19819
Location:168 → 349

DUF499; Protein of unknown function (DUF499)
NM_001259574.2 → NP_001246503.1 kenny, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246503.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9GYV5, Q9W105

UniProtKB/TrEMBL

A0A0B4K885, B6IDS7

Conserved Domains (2) summary

cd09803
Location:230 → 313

UBAN; polyubiquitin binding domain of NEMO and related proteins

cl19819
Location:168 → 351

DUF499; Protein of unknown function (DUF499)