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NKAIN Na,K-ATPase Interacting [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37979, updated on 10-May-2024

Summary

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Official Symbol
NKAINprovided by FlyBase
Official Full Name
Na,K-ATPase Interactingprovided by FlyBase
Primary source
FLYBASE:FBgn0085442
Locus tag
Dmel_CG34413
See related
AllianceGenome:FB:FBgn0085442
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.94; CG32836; CG34413; CG9047; Dmel\CG34413; dNKAIN
Old locus tag
CG32836; CG9047; Dmel_CG32836; Dmel_CG9047
Summary
Involved in regulation of sodium ion transport. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval visceral muscle cell; germ layer; and visceral muscle primordium. Orthologous to several human genes including NKAIN2 (sodium/potassium transporting ATPase interacting 2) and NKAIN4 (sodium/potassium transporting ATPase interacting 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
60E5-60E5; 2-107 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24881570..24888615)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20769093..20776138)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43466 Neighboring gene Ance-5 Neighboring gene Na channel protein 60E Neighboring gene uncharacterized protein Neighboring gene Thiamine pyrophosphate carrier protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel family of transmembrane proteins interacting with beta subunits of the Na,K-ATPase. Gorokhova S, et al. Hum Mol Genet, 2007 Oct 15. PMID 17606467
  2. Genetic and functional studies implicate synaptic overgrowth and ring gland cAMP/PKA signaling defects in the Drosophila melanogaster neurofibromatosis-1 growth deficiency. Walker JA, et al. PLoS Genet, 2013 Nov. PMID 24278035, Free PMC Article
  3. A genetic toolkit for tagging intronic MiMIC containing genes. Nagarkar-Jaiswal S, et al. Elife, 2015 Jun 23. PMID 26102525, Free PMC Article
  4. Drosophila glia: Few cell types and many conserved functions. Yildirim K, et al. Glia, 2019 Jan. PMID 30443934
  5. A Drosophila in vivo screen identifies store-operated calcium entry as a key regulator of adiposity. Baumbach J, et al. Cell Metab, 2014 Feb 4. PMID 24506874

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of sodium ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
Na,K-ATPase interacting
Names
CG34413-PF
CG34413-PG
CG34413-PH
CG34413-PI
CG34413-PJ
CG34413-PK
CG34413-PL
NKAIN-PF
NKAIN-PG
NKAIN-PH
NKAIN-PI
NKAIN-PJ
NKAIN-PK
NKAIN-PL

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24881570..24888615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299931.1 → NP_001286860.1  Na,K-ATPase interacting, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286860.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LGJ7, B9EQX8
    Conserved Domains (1) summary
    pfam05640
    Location:12 → 196
    NKAIN; Na,K-Atpase Interacting protein

  2. NM_001103979.4 → NP_001097449.2  Na,K-ATPase interacting, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097449.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86BN4
    Conserved Domains (1) summary
    pfam05640
    Location:12 → 181
    NKAIN; Na,K-Atpase Interacting protein

  3. NM_166694.3 → NP_726493.2  Na,K-ATPase interacting, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726493.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6MHQ4, Q8MMC8, Q961Q4
    UniProtKB/TrEMBL
    B5RJJ9, D2NUK1
    Conserved Domains (1) summary
    pfam05640
    Location:12 → 199
    NKAIN; Na,K-Atpase Interacting protein

  4. NM_166693.3 → NP_726492.2  Na,K-ATPase interacting, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726492.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6MHQ4, Q8MMC8, Q961Q4
    UniProtKB/TrEMBL
    B5RJJ9, D2NUK1
    Conserved Domains (1) summary
    pfam05640
    Location:12 → 199
    NKAIN; Na,K-Atpase Interacting protein

  5. NM_138131.4 → NP_611975.3  Na,K-ATPase interacting, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611975.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6MHQ4, Q8MMC8, Q961Q4
    UniProtKB/TrEMBL
    B5RJJ9, D2NUK1
    Conserved Domains (1) summary
    pfam05640
    Location:12 → 199
    NKAIN; Na,K-Atpase Interacting protein

  6. NM_001169826.3 → NP_001163297.1  Na,K-ATPase interacting, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163297.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B9EQX8, E1JGW7
    Conserved Domains (1) summary
    pfam05640
    Location:12 → 177
    NKAIN; Na,K-Atpase Interacting protein

  7. NM_001259577.2 → NP_001246506.1  Na,K-ATPase interacting, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246506.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6MHQ4, Q8MMC8, Q961Q4
    UniProtKB/TrEMBL
    B5RJJ9, D2NUK1
    Conserved Domains (1) summary
    pfam05640
    Location:12 → 199
    NKAIN; Na,K-Atpase Interacting protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LGJ7 A0A0B4LGJ7
A6MHQ4.1 A6MHQ4
B5RJJ9 B5RJJ9
E1JGW7 E1JGW7
Q86BN4 Q86BN4

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