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pomc.L proopiomelanocortin L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 380532, updated on 11-Apr-2024

Summary

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Official Symbol
pomc.L
Official Full Name
proopiomelanocortin L homeolog
Primary source
Xenbase:XB-GENE-483707
Locus tag
XELAEV_18028273mg
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
ACTH; aMSH; pomc; pomc-a; pomc-b; alpha-MSH
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Genomic context

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Location:
chromosome: 5L
Exon count:
3
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 5L NC_054379.1 (165058834..165064315, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 5L NC_030732.1 (154033936..154039471, complement)

Chromosome 5L - NC_054379.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121393862 Neighboring gene EFR3 homolog B L homeolog Neighboring gene angiopoietin-related protein 7 Neighboring gene stathmin 4 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Extracellular-signal regulated kinase regulates production of pro-opiomelanocortin in pituitary melanotroph cells. Kuribara M, et al. J Neuroendocrinol, 2011 Mar. PMID 21129045
  2. V-ATPase-mediated granular acidification is regulated by the V-ATPase accessory subunit Ac45 in POMC-producing cells. Jansen EJ, et al. Mol Biol Cell, 2010 Oct 1. PMID 20702583, Free PMC Article
  3. COP-binding sites in p24delta2 are necessary for proper secretory cargo biosynthesis. Strating JR, et al. Int J Biochem Cell Biol, 2009 Jul. PMID 19401156
  4. Expression of proopiomelanocortin and its cleavage enzyme genes in Rana esculenta and Xenopus laevis gonads. Carotti M, et al. Ann N Y Acad Sci, 2005 Apr. PMID 15891038
  5. Nucleotide sequence of cloned cDNA for pro-opiomelanocortin in the amphibian Xenopus laevis. Martens GJ, et al. J Biol Chem, 1985 Nov 5. PMID 3840481

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The evolution of pomc, pmch and pmchl genes and acquisition of hormonal status for MCHL explain different mechanisms used by vertebrates to background-adapt
    Title: Plasticity for colour adaptation in vertebrates explained by the evolution of the genes pomc, pmch and pmchl.
  2. Per1 showed temporal oscillations, regardless of the presence of melatonin or alpha-MSH, which slightly inhibited its expression.
    Title: Regulation of melanopsins and Per1 by α -MSH and melatonin in photosensitive Xenopus laevis melanophores.
  3. DCLK phosphorylation and nuclear translocation stimulate POMC gene expression in endocrine melanotrope cells.
    Title: ERK-regulated double cortin-like kinase (DCLK)-short phosphorylation and nuclear translocation stimulate POMC gene expression in endocrine melanotrope cells.
  4. Extracellular-signal regulated kinase regulates production of pro-opiomelanocortin in pituitary melanotroph cells.
    Title: Extracellular-signal regulated kinase regulates production of pro-opiomelanocortin in pituitary melanotroph cells.
  5. The V-ATPase accessory subunit Ac45 represents the first regulator of the proton pump and controls V-ATPase-mediated granular acidification that is necessary for efficient prohormone processing.
    Title: V-ATPase-mediated granular acidification is regulated by the V-ATPase accessory subunit Ac45 in POMC-producing cells.
  6. The p24 proteins fulfil their role in secretory protein biosynthesis via COPI- or COPII-coated transport vesicles.
    Title: COP-binding sites in p24delta2 are necessary for proper secretory cargo biosynthesis.
  7. In the melanotrope, biosynthesis and processing occur along a secretory granule maturation axis and light controls the biosynthesis and secretion of POMC end-products.
    Title: Activity-dependent dynamics of coexisting brain-derived neurotrophic factor, pro-opiomelanocortin and alpha-melanophore-stimulating hormone in melanotrope cells of Xenopus laevis.
  8. Gonadal POMC convertase gene expression is demonstrated in Xenopus laevis.
    Title: Expression of proopiomelanocortin and its cleavage enzyme genes in Rana esculenta and Xenopus laevis gonads.
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General gene information

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Homology

Clone Names

  • MGC64273

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables G protein-coupled receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables hormone activity IEA
Inferred from Electronic Annotation
more info
  
enables neuropeptide hormone activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of corticosterone secretion IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in secretory granule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pro-opiomelanocortin A
Names
adrenocorticotropic hormone
alpha-melanophore stimulating hormone
corticotropin
corticotropin-lipotropin A
proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)
proopiomelanocortin A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001087369.2 → NP_001080838.1  pro-opiomelanocortin A precursor

    See identical proteins and their annotated locations for NP_001080838.1

    Status: PROVISIONAL

    Source sequence(s)
    BC054160
    UniProtKB/Swiss-Prot
    P06298, P87464, Q91824, Q9PU10
    UniProtKB/TrEMBL
    A0A974CTC5
    Conserved Domains (3) summary
    pfam00976
    Location:210 → 228
    ACTH_domain; Corticotropin ACTH domain
    pfam08035
    Location:229 → 256
    Op_neuropeptide; Opioids neuropeptide
    pfam08384
    Location:27 → 69
    NPP; Pro-opiomelanocortin, N-terminal region

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054379.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    165058834..165064315 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06298.2 GenPept UniProtKB/Swiss-Prot:P06298

Gene LinkOut

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