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Tagap1 T cell activation GTPase activating protein 1 [ Mus musculus (house mouse) ]

Gene ID: 380608, updated on 8-Feb-2024

Summary

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Official Symbol
Tagap1provided by MGI
Official Full Name
T cell activation GTPase activating protein 1provided by MGI
Primary source
MGI:MGI:1919786
See related
Ensembl:ENSMUSG00000052031 AllianceGenome:MGI:1919786
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FKSG15; 2610315E15Rik
Summary
Predicted to enable GTPase activator activity. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus 21. Orthologous to human TAGAP (T cell activation RhoGTPase activating protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 24.9), thymus adult (RPKM 22.7) and 28 other tissues See more
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Genomic context

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Location:
17 A1; 17 4.55 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (7222364..7246122, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (6954965..6961565, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700122H20 gene Neighboring gene radial spoke 3B homolog (Chlamydomonas) Neighboring gene STARR-positive B cell enhancer mm9_chr17:7165470-7165771 Neighboring gene STARR-positive B cell enhancer ABC_E2470 Neighboring gene STARR-seq mESC enhancer starr_41744 Neighboring gene ribonuclease T2B Neighboring gene predicted gene 1604b Neighboring gene predicted gene, 25119

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel group of multi-GAP-domain proteins. Ruan Y, et al. Mol Reprod Dev, 2008 Oct. PMID 18363199, Free PMC Article
  2. The t complex-encoded GTPase-activating protein Tagap1 acts as a transmission ratio distorter in mice. Bauer H, et al. Nat Genet, 2005 Sep. PMID 16116428
  3. Lineage-specific biology revealed by a finished genome assembly of the mouse. Church DM, et al. PLoS Biol, 2009 May 5. PMID 19468303, Free PMC Article
  4. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
T-cell activation GTPase-activating protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_147155.2 → NP_671511.2  T-cell activation GTPase-activating protein 1

    See identical proteins and their annotated locations for NP_671511.2

    Status: VALIDATED

    Source sequence(s)
    AC122413, AV444953, BQ555561
    Consensus CDS
    CCDS49940.1
    UniProtKB/Swiss-Prot
    P0CAX8
    Related
    ENSMUSP00000070466.7, ENSMUST00000063683.8
    Conserved Domains (1) summary
    cl02570
    Location:52 → 72
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    7222364..7246122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160658.1 → XP_036016551.1  T-cell activation GTPase-activating protein 1 isoform X1

  2. XM_011246178.4 → XP_011244480.1  T-cell activation GTPase-activating protein 1 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001001393.1: Suppressed sequence

    Description
    NM_001001393.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CAX8.1 GenPept UniProtKB/Swiss-Prot:P0CAX8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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