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Tlcd2 TLC domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 380712, updated on 5-Mar-2024

Summary

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Official Symbol
Tlcd2provided by MGI
Official Full Name
TLC domain containing 2provided by MGI
Primary source
MGI:MGI:1917141
See related
Ensembl:ENSMUSG00000038217 AllianceGenome:MGI:1917141
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be involved in several processes, including membrane assembly; phospholipid homeostasis; and regulation of membrane lipid distribution. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system and retina. Orthologous to human TLCD2 (TLC domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 69.7), duodenum adult (RPKM 20.6) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Tlcd2 in Genome Data Viewer
Location:
11 B5; 11 45.91 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (75358771..75361725)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (75468024..75470899)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain 81 Neighboring gene STARR-positive B cell enhancer ABC_E3973 Neighboring gene STARR-positive B cell enhancer ABC_E10687 Neighboring gene STARR-seq mESC enhancer starr_29995 Neighboring gene Mir22 host gene (non-protein coding) Neighboring gene microRNA 22 Neighboring gene STARR-positive B cell enhancer ABC_E591 Neighboring gene pre-mRNA processing factor 8 Neighboring gene STARR-positive B cell enhancer ABC_E7017 Neighboring gene Rab interacting lysosomal protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • 2010305C02Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in membrane assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in membrane assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in plasma membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in plasma membrane organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of membrane lipid distribution IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of membrane lipid distribution ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
TLC domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291156.1 → NP_001278085.1  TLC domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001278085.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AI549721, AK008522, CO044816, CV562896
    Consensus CDS
    CCDS70238.1
    UniProtKB/Swiss-Prot
    Q8VC26
    Related
    ENSMUSP00000104074.2, ENSMUST00000108435.2
    Conserved Domains (1) summary
    cl02759
    Location:33 → 143
    TRAM_LAG1_CLN8; TLC domain

  2. NM_027249.3 → NP_081525.1  TLC domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_081525.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI549721, AL591496, CO044816, CV562896
    Consensus CDS
    CCDS48850.1
    UniProtKB/Swiss-Prot
    Q8VC26, Q9D837
    Related
    ENSMUSP00000042958.8, ENSMUST00000043598.14
    Conserved Domains (1) summary
    smart00724
    Location:33 → 225
    TLC; TRAM, LAG1 and CLN8 homology domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    75358771..75361725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249099.2 → XP_011247401.1  TLC domain-containing protein 2 isoform X1

    Conserved Domains (1) summary
    cl02759
    Location:33 → 143
    TRAM_LAG1_CLN8; TLC domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VC26.1 GenPept UniProtKB/Swiss-Prot:Q8VC26

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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