Zfp395 zinc finger protein 395 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp395provided by MGI
Official Full Name: zinc finger protein 395provided by MGI
Primary source: MGI:MGI:2682318
See related: Ensembl:ENSMUSG00000034522 AllianceGenome:MGI:2682318
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm910
Summary: Enables cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nuclear speck. Predicted to be active in nucleus. Is expressed in several structures, including aorta; brain; endocrine gland; gallbladder; and genitourinary system. Orthologous to human ZNF395 (zinc finger protein 395). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in limb E14.5 (RPKM 20.0), ovary adult (RPKM 19.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D1; 14 34.32 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (65595796..65636379)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (65358676..65398930)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Highly related cDNAs Pbf and Gig1 interact with required element MyoD core enhancer; they represents a new family of DNA binding proteins that may be components of transciptional pathways that regulate a number of developmental and physiologic processes.
Title: Cloning and characterization of a novel MyoD enhancer-binding factor.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger protein 395

Names: papillomavirus regulatory factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199029.2 → NP_950194.2 zinc finger protein 395

See identical proteins and their annotated locations for NP_950194.2

Status: VALIDATED

Source sequence(s)

AC158983, AI425685, BY117447, BY780785, CF737135

Consensus CDS

CCDS49522.1

UniProtKB/TrEMBL

E9Q5N9, Q3U227

Related

ENSMUSP00000064422.7, ENSMUST00000066994.7

Conserved Domains (1) summary

pfam15997
Location:4 → 110

DUF4772; Domain of unknown function (DUF4772)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

65595796..65636379

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158689.1 → XP_036014582.1 zinc finger protein 395 isoform X1

UniProtKB/TrEMBL

E9Q5N9, Q3U227

Conserved Domains (1) summary

pfam15997
Location:4 → 110

DUF4772; Domain of unknown function (DUF4772)
XM_011245097.3 → XP_011243399.1 zinc finger protein 395 isoform X1

See identical proteins and their annotated locations for XP_011243399.1

UniProtKB/TrEMBL

E9Q5N9, Q3U227

Conserved Domains (1) summary

pfam15997
Location:4 → 110

DUF4772; Domain of unknown function (DUF4772)