U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Capn13 calpain 13 [ Mus musculus (house mouse) ]

Gene ID: 381122, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Capn13provided by MGI
Official Full Name
calpain 13provided by MGI
Primary source
MGI:MGI:2685789
See related
Ensembl:ENSMUSG00000043705 AllianceGenome:MGI:2685789
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm943; CANP 13
Summary
Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in negative regulation of apoptotic process and proteolysis. Predicted to be active in cytoplasm. Orthologous to human CAPN13 (calpain 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 6.9), colon adult (RPKM 6.5) and 4 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Capn13 in Genome Data Viewer
Location:
17 E2; 17 44.84 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (73613451..73706376, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (73306456..73399381, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene lysocardiolipin acyltransferase 1 Neighboring gene predicted gene, 25406 Neighboring gene RIKEN cDNA E330032C10 gene Neighboring gene STARR-positive B cell enhancer ABC_E398 Neighboring gene STARR-positive B cell enhancer ABC_E10970 Neighboring gene STARR-positive B cell enhancer ABC_E7556 Neighboring gene STARR-seq mESC enhancer starr_43202 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 14 Neighboring gene predicted gene, 46602 Neighboring gene predicted gene, 52320

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. SHARPIN negatively associates with TRAF2-mediated NFκB activation. Liang Y. PLoS One, 2011. PMID 21829440, Free PMC Article
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
calpain-13
Names
calcium-activated neutral proteinase 13

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033444.2 → NP_001028616.1  calpain-13

    See identical proteins and their annotated locations for NP_001028616.1

    Status: PROVISIONAL

    Source sequence(s)
    AK136569
    Consensus CDS
    CCDS37690.1
    UniProtKB/Swiss-Prot
    B2RW21, Q3UW68
    Related
    ENSMUSP00000092832.4, ENSMUST00000095208.4
    Conserved Domains (2) summary
    pfam00648
    Location:31 → 327
    Peptidase_C2; Calpain family cysteine protease
    cl00165
    Location:343 → 469
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    73613451..73706376 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317548.2 → XP_017173037.1  calpain-13 isoform X1

    Conserved Domains (3) summary
    cd16195
    Location:340 → 500
    EFh_PEF_CAPN13_14; Penta-EF hand, calcium binding motifs, found in calpain-13 (CAPN13), calpain-14 (CAPN14), and similar proteins
    pfam00648
    Location:16 → 162
    Peptidase_C2; Calpain family cysteine protease
    cl00165
    Location:201 → 304
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...

  2. XM_006524535.2 → XP_006524598.1  calpain-13 isoform X2

    Conserved Domains (1) summary
    pfam00648
    Location:31 → 327
    Peptidase_C2; Calpain family cysteine protease

RNA

  1. XR_001782085.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UW68.1 GenPept UniProtKB/Swiss-Prot:Q3UW68

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous